Tetrodotoxin protects against acute ischemic renal failure in the rat

W. J. Li, S. M. Bergman, R. P. Holmes, J. W. Strandhoy, Rajash Handa, D. L. McCullough

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Tetrodotoxin has been reported to cause prolonged systemic hypotension without resultant ischemic damage. We tested its ability to protect the kidney during 60 minutes of warm ischemia in uninephrectomized rats. Protection was observed when tetrodotoxin was given intravenously at two μg./kg. and four μg./kg. as assessed by serial plasma blood urea nitrogen and creatinine measurements over two weeks. Tetrodotoxin was protective when given immediately before or immediately after the ischemic period. The renal protection of tetrodotoxin was not due to its effects on renal nerves as renal denervation did not protect the kidney from the ischemic damage. The renal protective effects of four μg. tetrodotoxin/kg. were similar to those of four mg. captopril/kg. but the combination of the two was paradoxically without effect. We tested whether tetrodotoxin and captopril chemically antagonized each other, but in the presence of tetrodotoxin, captopril was still a potent inhibitor of the conversion of angiotensin I to angiotensin II. These results indicate that tetrodotoxin could be useful in elucidating the sequence of events associated with ischemic-reperfusion renal injury and in identifying ways of preserving renal function during renal surgery.

Original languageEnglish (US)
Pages (from-to)519-522
Number of pages4
JournalJournal of Urology
Volume147
Issue number2
StatePublished - 1992
Externally publishedYes

Fingerprint

Tetrodotoxin
Acute Kidney Injury
Kidney
Captopril
Warm Ischemia
Angiotensin I
Blood Urea Nitrogen
Denervation
Reperfusion Injury
Angiotensin II
Hypotension
Creatinine

Keywords

  • ischemia
  • kidney transplantation
  • tetrodotoxin

ASJC Scopus subject areas

  • Urology

Cite this

Li, W. J., Bergman, S. M., Holmes, R. P., Strandhoy, J. W., Handa, R., & McCullough, D. L. (1992). Tetrodotoxin protects against acute ischemic renal failure in the rat. Journal of Urology, 147(2), 519-522.

Tetrodotoxin protects against acute ischemic renal failure in the rat. / Li, W. J.; Bergman, S. M.; Holmes, R. P.; Strandhoy, J. W.; Handa, Rajash; McCullough, D. L.

In: Journal of Urology, Vol. 147, No. 2, 1992, p. 519-522.

Research output: Contribution to journalArticle

Li, WJ, Bergman, SM, Holmes, RP, Strandhoy, JW, Handa, R & McCullough, DL 1992, 'Tetrodotoxin protects against acute ischemic renal failure in the rat', Journal of Urology, vol. 147, no. 2, pp. 519-522.
Li WJ, Bergman SM, Holmes RP, Strandhoy JW, Handa R, McCullough DL. Tetrodotoxin protects against acute ischemic renal failure in the rat. Journal of Urology. 1992;147(2):519-522.
Li, W. J. ; Bergman, S. M. ; Holmes, R. P. ; Strandhoy, J. W. ; Handa, Rajash ; McCullough, D. L. / Tetrodotoxin protects against acute ischemic renal failure in the rat. In: Journal of Urology. 1992 ; Vol. 147, No. 2. pp. 519-522.
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