TGFβ superfamily signaling in the neural crest lineage

Simon J. Conway, Vesa Kaartinen

Research output: Contribution to journalComment/debate

7 Scopus citations


The neural crest cell (NCC) lineage is often referred to as the fourth germ layer in embryos, as its wide range of migration and early colonization of multiple tissues and organ systems throughout the developing body is astounding. Many human birth defects are thought to have their origins within the NCC lineage. Exciting recent conditional mouse targeting and transgenic combinatorial suppression approaches have revealed that the TGFβ superfamily is a key signaling pathway within the cardiac and cranial NCC subpopulations. Given the complexity of TGFβ superfamily signaling and that multiple ligand and receptor combinations have already been shown to be expressed within the NCC subpopulations, and the difficulty in transgenically targeting entire signaling cascades, we review several up-to-date transgenic approaches that are revealing unexpected consequences.

Original languageEnglish (US)
JournalCell Adhesion and Migration
Issue number3
StatePublished - Jan 1 2011


  • Cranial crest
  • Heart
  • Mouse transgenics
  • Neural crest
  • TGF beta

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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