TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis

Delphine Javelaud, Vasileia I. Alexaki, Sylviane Dennler, Khalid Mohammad, Theresa Guise, Alain Mauviel

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.

Original languageEnglish
Pages (from-to)5606-5610
Number of pages5
JournalCancer Research
Volume71
Issue number17
DOIs
StatePublished - Sep 1 2011

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Neoplasm Metastasis
Neoplasms
Embryonic Development
Cell Differentiation
Transcription Factors
Cell Proliferation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis. / Javelaud, Delphine; Alexaki, Vasileia I.; Dennler, Sylviane; Mohammad, Khalid; Guise, Theresa; Mauviel, Alain.

In: Cancer Research, Vol. 71, No. 17, 01.09.2011, p. 5606-5610.

Research output: Contribution to journalArticle

Javelaud, Delphine ; Alexaki, Vasileia I. ; Dennler, Sylviane ; Mohammad, Khalid ; Guise, Theresa ; Mauviel, Alain. / TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis. In: Cancer Research. 2011 ; Vol. 71, No. 17. pp. 5606-5610.
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