TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis

Delphine Javelaud, Vasileia I. Alexaki, Sylviane Dennler, Khalid S. Mohammad, Theresa A. Guise, Alain Mauviel

Research output: Contribution to journalShort survey

120 Scopus citations


The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.

Original languageEnglish (US)
Pages (from-to)5606-5610
Number of pages5
JournalCancer Research
Issue number17
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Javelaud, D., Alexaki, V. I., Dennler, S., Mohammad, K. S., Guise, T. A., & Mauviel, A. (2011). TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Research, 71(17), 5606-5610.