Th1 cells regulate hematopoietic progenitor cell homeostasis by production of Oncostatin M

Hal E. Broxmeyer, Heather A. Bruns, Shangming Zhang, Scott Cooper, Giao Hangoc, Andrew N.J. McKenzie, Alexander L. Dent, Ulrike Schindler, Lisa K. Naeger, Timothy Hoey, Mark H. Kaplan

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Regulation of hematopoietic progenitor cell homeostasis is crucial for maintenance of innate immunity and the ability of the body to respond to injury and infection. In this report, we demonstrate that progenitor cell numbers and cycling status in vivo are dramatically increased in mice deficient in Stat6 and decreased in mice deficient in Stat4, targeted mutations which also alter T helper cell polarization. Experiments using mice that have T cell restricted transgenic expression of Stat4 or Stat6 or have been in vivo depleted of T cell subsets demonstrate that CD4+ T cells regulate progenitor cell activity. Injection of the Th1 cytokine Oncostatin M but not other cytokines into Stat4-deficient mice recovers progenitor cell activity to wild-type levels. Thus, T helper cells actively regulate hematopoietic progenitor cell homeostasis.

Original languageEnglish (US)
Pages (from-to)815-825
Number of pages11
JournalImmunity
Volume16
Issue number6
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Broxmeyer, H. E., Bruns, H. A., Zhang, S., Cooper, S., Hangoc, G., McKenzie, A. N. J., Dent, A. L., Schindler, U., Naeger, L. K., Hoey, T., & Kaplan, M. H. (2002). Th1 cells regulate hematopoietic progenitor cell homeostasis by production of Oncostatin M. Immunity, 16(6), 815-825. https://doi.org/10.1016/S1074-7613(02)00319-9