Th2 response polarization during infection with die helminth parasite Schistosoma mansoni

Edward J. Pearce, Colleen M. Kane, Jie Sun, Justin J. Taylor, Amy S. McKee, Laura Cervi

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

T-helper 2 (Th2) cell responses play a critical role in protection against helminth infections. In the case of Schistosoma mansoni, an important helminth parasite of man, data from a mouse model of human disease have shown that Th2 responses are essential to allow host survival. In this infection, parasite eggs are the primary stimulus for Th2 response development. Recent work has shown that egg molecules exert multiple levels of control over the development of host interferon-γ-associated inflammatory responses. Soluble egg antigen inhibits the ability of dendritic cells to make interleukin-12 and induces Th2-polarized adaptive immune responses that in combination with regulatory T-cell responses effectively limit Th1 response development. In this article, we discuss the factors influencing Th2 response polarization during infection with S. mansoni.

Original languageEnglish (US)
Pages (from-to)117-126
Number of pages10
JournalImmunological Reviews
Volume201
DOIs
StatePublished - Oct 2004
Externally publishedYes

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Schistosoma mansoni
Helminths
Ovum
Parasites
Schistosomiasis mansoni
Th2 Cells
Adaptive Immunity
Regulatory T-Lymphocytes
Interleukin-12
Infection
Interleukin-1
Dendritic Cells
Interferons
Eggs
Antigens
Survival

ASJC Scopus subject areas

  • Immunology

Cite this

Th2 response polarization during infection with die helminth parasite Schistosoma mansoni. / Pearce, Edward J.; Kane, Colleen M.; Sun, Jie; Taylor, Justin J.; McKee, Amy S.; Cervi, Laura.

In: Immunological Reviews, Vol. 201, 10.2004, p. 117-126.

Research output: Contribution to journalArticle

Pearce, Edward J. ; Kane, Colleen M. ; Sun, Jie ; Taylor, Justin J. ; McKee, Amy S. ; Cervi, Laura. / Th2 response polarization during infection with die helminth parasite Schistosoma mansoni. In: Immunological Reviews. 2004 ; Vol. 201. pp. 117-126.
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