Th9 Cells as Targets for Immunotherapy

O. Awe, M. H. Kaplan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The secretion of specific cytokines distinguishes T helper cell subsets and confers the ability of the T cell to promote distinct types of inflammation. The restricted nature of cytokine production among these subsets makes them attractive therapeutic targets. The interleukin (IL)-9-secreting subset termed Th9 cells are observed in patients and in mouse models associated with immunity to parasite infections, autoimmunity, tumor immunity, and allergic inflammation. The conservation of Th9 phenotype and function across evolution suggests that Th9 cells play a prominent role in effective immunity. In this chapter we outline preclinical mouse studies and human studies that demonstrate a role for Th9/IL-9 in the pathogenesis of atopic disease, colitis, central nervous system paralysis, and protection against helminthic parasite infection and tumor progression. We further outline current therapeutics that might be used to modulate Th9 activity in a clinical setting.

Original languageEnglish (US)
Title of host publicationTranslational Immunology
Subtitle of host publicationMechanisms and Pharmacologic Approaches
PublisherElsevier Inc.
Pages165-184
Number of pages20
ISBN (Print)9780128015773
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Allergy
  • Asthma
  • Autoimmunity
  • Helminths
  • IL-9
  • T helper cell
  • Therapy
  • Tumor immunity

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Awe, O., & Kaplan, M. H. (2016). Th9 Cells as Targets for Immunotherapy. In Translational Immunology: Mechanisms and Pharmacologic Approaches (pp. 165-184). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801577-3.00007-1