Th9 cells: Differentiation and disease

Research output: Contribution to journalArticle

178 Scopus citations

Abstract

CD4+ T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo.

Original languageEnglish (US)
Pages (from-to)104-115
Number of pages12
JournalImmunological Reviews
Volume252
Issue number1
DOIs
StatePublished - Mar 2013

Keywords

  • Differentiation
  • Inflammation
  • T cells
  • T-helper cells
  • Transcription factor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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