The 20,000-dalton variant of human growth hormone: Location of the amino acid deletions

U. J. Lewis, L. F. Bonewald, L. J. Lewis

Research output: Contribution to journalArticle

136 Scopus citations


The 20,000-dalton variant of human growth hormone lacks a sequence of 15 amino acids normally found in the hormone. The deletion involves residues 32 through 46. The remainder of the molecule is identical to the larger form of the hormone. These results suggest that the variant is the product of a deletion mutation in the growth hormone gene.

Original languageEnglish (US)
Pages (from-to)511-516
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jan 29 1980
Externally publishedYes


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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