The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome

Tammy Yanovitch, David K. Wallace, Sharon F. Freedman, Laura B. Enyedi, Priya Kishnani, Gordon Worley, Blythe Crissman, Erica Burner, Terri L. Young

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Children with Down syndrome (DS) have an increased prevalence of ocular disorders, including amblyopia, strabismus, and refractive error. Health maintenance guidelines from the Down Syndrome Medical Interest Group recommend ophthalmologic examinations every 1 to 2 years for these children. Photoscreening may be a cost-effective option for subsequent screening evaluations after an initial complete examination, but no study has evaluated the accuracy of photoscreening in children with DS. The purpose of this study is to determine the sensitivity, specificity, and positive and negative predictive values of photoscreening in detecting treatable ocular conditions in children with DS. Methods: Photoscreening and complete ophthalmologic evaluations were performed in 50 consecutive 3- to 10-year-old children with DS. Sensitivity, specificity, and positive and negative predictive values were calculated with the use of ophthalmologic examination findings as the reference standard. Results: Most children were able to complete photoscreening (94% with Medical Technology and Innovations [MTI] and 90% with Visiscreen OSS-C [VR]). Many children had an identified diagnosis on ophthalmologic examination (n = 46, 92%). Of these, approximately one-half (n = 27, 54%) had one or more condition(s) requiring treatment. Both the MTI and VR photoscreening devices had a sensitivity of 93% (95% confidence interval 0.76-0.99) for detecting treatable ocular conditions. The specificities for the MTI and VR photoscreening were 0.35 (0.18-0.57) and 0.55 (0.34-0.74), respectively. Conclusions: Photoscreening is sensitive but less specific at detecting treatable ocular conditions in children with DS. In specific instances, the use of photoscreening in the DS population has the potential to save time and expense related to routine eye examinations, particularly in children with a normal baseline comprehensive examination.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalJournal of AAPOS
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Down Syndrome
Technology
Sensitivity and Specificity
Public Opinion
Amblyopia
Refractive Errors
Strabismus
Guidelines
Confidence Intervals
Costs and Cost Analysis
Equipment and Supplies
Health

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

Cite this

The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome. / Yanovitch, Tammy; Wallace, David K.; Freedman, Sharon F.; Enyedi, Laura B.; Kishnani, Priya; Worley, Gordon; Crissman, Blythe; Burner, Erica; Young, Terri L.

In: Journal of AAPOS, Vol. 14, No. 6, 01.12.2010, p. 472-477.

Research output: Contribution to journalArticle

Yanovitch, T, Wallace, DK, Freedman, SF, Enyedi, LB, Kishnani, P, Worley, G, Crissman, B, Burner, E & Young, TL 2010, 'The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome', Journal of AAPOS, vol. 14, no. 6, pp. 472-477. https://doi.org/10.1016/j.jaapos.2010.09.016
Yanovitch, Tammy ; Wallace, David K. ; Freedman, Sharon F. ; Enyedi, Laura B. ; Kishnani, Priya ; Worley, Gordon ; Crissman, Blythe ; Burner, Erica ; Young, Terri L. / The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome. In: Journal of AAPOS. 2010 ; Vol. 14, No. 6. pp. 472-477.
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abstract = "Background: Children with Down syndrome (DS) have an increased prevalence of ocular disorders, including amblyopia, strabismus, and refractive error. Health maintenance guidelines from the Down Syndrome Medical Interest Group recommend ophthalmologic examinations every 1 to 2 years for these children. Photoscreening may be a cost-effective option for subsequent screening evaluations after an initial complete examination, but no study has evaluated the accuracy of photoscreening in children with DS. The purpose of this study is to determine the sensitivity, specificity, and positive and negative predictive values of photoscreening in detecting treatable ocular conditions in children with DS. Methods: Photoscreening and complete ophthalmologic evaluations were performed in 50 consecutive 3- to 10-year-old children with DS. Sensitivity, specificity, and positive and negative predictive values were calculated with the use of ophthalmologic examination findings as the reference standard. Results: Most children were able to complete photoscreening (94{\%} with Medical Technology and Innovations [MTI] and 90{\%} with Visiscreen OSS-C [VR]). Many children had an identified diagnosis on ophthalmologic examination (n = 46, 92{\%}). Of these, approximately one-half (n = 27, 54{\%}) had one or more condition(s) requiring treatment. Both the MTI and VR photoscreening devices had a sensitivity of 93{\%} (95{\%} confidence interval 0.76-0.99) for detecting treatable ocular conditions. The specificities for the MTI and VR photoscreening were 0.35 (0.18-0.57) and 0.55 (0.34-0.74), respectively. Conclusions: Photoscreening is sensitive but less specific at detecting treatable ocular conditions in children with DS. In specific instances, the use of photoscreening in the DS population has the potential to save time and expense related to routine eye examinations, particularly in children with a normal baseline comprehensive examination.",
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AU - Wallace, David K.

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AU - Enyedi, Laura B.

AU - Kishnani, Priya

AU - Worley, Gordon

AU - Crissman, Blythe

AU - Burner, Erica

AU - Young, Terri L.

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AB - Background: Children with Down syndrome (DS) have an increased prevalence of ocular disorders, including amblyopia, strabismus, and refractive error. Health maintenance guidelines from the Down Syndrome Medical Interest Group recommend ophthalmologic examinations every 1 to 2 years for these children. Photoscreening may be a cost-effective option for subsequent screening evaluations after an initial complete examination, but no study has evaluated the accuracy of photoscreening in children with DS. The purpose of this study is to determine the sensitivity, specificity, and positive and negative predictive values of photoscreening in detecting treatable ocular conditions in children with DS. Methods: Photoscreening and complete ophthalmologic evaluations were performed in 50 consecutive 3- to 10-year-old children with DS. Sensitivity, specificity, and positive and negative predictive values were calculated with the use of ophthalmologic examination findings as the reference standard. Results: Most children were able to complete photoscreening (94% with Medical Technology and Innovations [MTI] and 90% with Visiscreen OSS-C [VR]). Many children had an identified diagnosis on ophthalmologic examination (n = 46, 92%). Of these, approximately one-half (n = 27, 54%) had one or more condition(s) requiring treatment. Both the MTI and VR photoscreening devices had a sensitivity of 93% (95% confidence interval 0.76-0.99) for detecting treatable ocular conditions. The specificities for the MTI and VR photoscreening were 0.35 (0.18-0.57) and 0.55 (0.34-0.74), respectively. Conclusions: Photoscreening is sensitive but less specific at detecting treatable ocular conditions in children with DS. In specific instances, the use of photoscreening in the DS population has the potential to save time and expense related to routine eye examinations, particularly in children with a normal baseline comprehensive examination.

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