The acute effect of phenylpropanolamine and brompheniramine on blood pressure in controlled hypertension - A randomized double-blind crossover trial

Alice Stollenwerk Petrulis, Thomas Imperiale, Theodore Speroff

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Study objective:To determine the acute effect of phenylpropanolamine, 75 mg, and brompheniramine, 12 mg, in combination (PPA/B) on blood pressure in patients with controlled hypertension, using ambulatory blood pressure monitoring (ABPM). Design:Randomized double-blind crossover trial. Setting:Outpatient clinic at one medical center. Participants:13 healthy volunteers aged 36 to 64 years, receiving medication for hypertension. Interventions:Following 24-hour baseline ABPM, participants were randomized to receive either placebo or PPA/B every 12 hours for three doses, while ABPM continued. After a 24-hour washout period, all participants received the crossover regimen. Measurements and main results:No clinically important or statistically significant difference was noted for mean systolic and diastolic blood pressures during the baseline (125/75), PPA/B (127/72), and placebo (126/73) phases of the study. Within the first four hours of treatment, the mean change in systolic blood pressure from baseline between PPA/B and placebo phases was 1.7 mm Hg (95% CI -5.3 to 8.7), and mean change in diastolic blood pressure was 0.9 mm Hg (95% CI -1.6 to 3.5), excluding a first-dose pressor effect. Conclusion:When used as recommended, PPA/B, a commonly used over-the-counter cold medication, has no significant acute effect on blood pressure in patients with controlled hypertension.

Original languageEnglish (US)
Pages (from-to)503-506
Number of pages4
JournalJournal of General Internal Medicine
Volume6
Issue number6
DOIs
StatePublished - Nov 1991
Externally publishedYes

Fingerprint

Brompheniramine
Phenylpropanolamine
Cross-Over Studies
Blood Pressure
Hypertension
Ambulatory Blood Pressure Monitoring
Placebos
Ambulatory Care Facilities
Healthy Volunteers

Keywords

  • blood pressure
  • brompheniramine
  • decongestants
  • hypertension
  • phenylpropanolamine
  • sympathomimetics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The acute effect of phenylpropanolamine and brompheniramine on blood pressure in controlled hypertension - A randomized double-blind crossover trial. / Petrulis, Alice Stollenwerk; Imperiale, Thomas; Speroff, Theodore.

In: Journal of General Internal Medicine, Vol. 6, No. 6, 11.1991, p. 503-506.

Research output: Contribution to journalArticle

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abstract = "Study objective:To determine the acute effect of phenylpropanolamine, 75 mg, and brompheniramine, 12 mg, in combination (PPA/B) on blood pressure in patients with controlled hypertension, using ambulatory blood pressure monitoring (ABPM). Design:Randomized double-blind crossover trial. Setting:Outpatient clinic at one medical center. Participants:13 healthy volunteers aged 36 to 64 years, receiving medication for hypertension. Interventions:Following 24-hour baseline ABPM, participants were randomized to receive either placebo or PPA/B every 12 hours for three doses, while ABPM continued. After a 24-hour washout period, all participants received the crossover regimen. Measurements and main results:No clinically important or statistically significant difference was noted for mean systolic and diastolic blood pressures during the baseline (125/75), PPA/B (127/72), and placebo (126/73) phases of the study. Within the first four hours of treatment, the mean change in systolic blood pressure from baseline between PPA/B and placebo phases was 1.7 mm Hg (95{\%} CI -5.3 to 8.7), and mean change in diastolic blood pressure was 0.9 mm Hg (95{\%} CI -1.6 to 3.5), excluding a first-dose pressor effect. Conclusion:When used as recommended, PPA/B, a commonly used over-the-counter cold medication, has no significant acute effect on blood pressure in patients with controlled hypertension.",
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