The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat

Bryan Yamamoto, Linda J. Spanos

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine ((±)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical detection. Monitored over a 3 h period, the magnitude of increase in dopamine release and the onset of effect were dose-dependent and similar for both brain areas following the 2.5 and 5 mg/kg dose of the drug. However, responses were different for these brain regions using 10 mg/kg of MDMA; the magnitude of increase was greater and the onset of effect more immediate in caudate. Analysis of dopamine and DOPAC tissue content in both caudate and nucleus accumbens verified the voltammetry results. This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalEuropean Journal of Pharmacology
Volume148
Issue number2
DOIs
StatePublished - Mar 29 1988
Externally publishedYes

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Dopamine
Caudate Nucleus
Nucleus Accumbens
3,4-Dihydroxyphenylacetic Acid
Brain
Amphetamine
Appointments and Schedules
High Pressure Liquid Chromatography
Pharmaceutical Preparations

Keywords

  • 3,4-Methylenedioxymethamphetamine (MDMA)
  • Caudate nucleus
  • Dopamine metabolism
  • Dopamine release
  • Nucleus accumbens
  • Voltammetry

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat. / Yamamoto, Bryan; Spanos, Linda J.

In: European Journal of Pharmacology, Vol. 148, No. 2, 29.03.1988, p. 195-203.

Research output: Contribution to journalArticle

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