The alcohol clamp: Applications, challenges, and new directions - An RSA 2004 symposium summary

Vijay A. Ramchandani, Sean O'Connor, Yehuda Neumark, Ulrich S. Zimmermann, Sandra Morzorati, Harriet De Wit

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This article summarizes the proceedings of a symposium organized and cochaired by Vijay Ramchandani and Sean O'Connor and presented at the 2004 Research Society on Alcoholism meeting in Vancouver, BC, Canada. The objectives of this symposium were: (1) to provide a rationale for the development and use of the alcohol clamp and the requirements for its use in alcohol challenge studies; (2) to highlight recent studies conducted using the alcohol clamp to identify sources of variation in the pharmacokinetics and pharmacodynamics of alcohol, as well as to address important research questions related to the relationship between the response to alcohol and the risk for alcoholism; and (3) to provide a perspective on progress, address limitations of the clamp, and identify new directions for alcohol challenge research. The symposium began with an introduction and overview of the alcohol clamp, by Vijay Ramchandani. This was followed by 4 presentations that highlighted recent studies conducted using the clamp including: (1) determination of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in a male Jewish population, by Yehuda Neumark; (2) examination of family history of alcoholism, recent drinking history, and levels and rates of administration as determinants of the response to alcohol and risk for alcoholism, by Sean O'Connor; (3) evaluation of the time course of ethanol intoxication on neuroendocrine function in humans, by Ulrich Zimmermann; and (4) a study of the effects of steady-state blood alcohol levels on auditory event-related potentials in rats, by Sandra Morzorati. Harriet de Wit summarized and discussed the research presented at the symposium and provided her perspective on future directions for research using the alcohol clamp.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume30
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Clamping devices
Alcohols
Alcoholism
Research
Direction compound
Pharmacodynamics
Wit and Humor
Alcohol Dehydrogenase
Pharmacokinetics
Evoked Potentials
Polymorphism
Drinking
Canada
Ethanol
Rats
Blood

Keywords

  • ADH
  • Alcohol Clamp
  • Alcohol Elimination Rate
  • Auditory Event-Related Potentials
  • Family History of Alcoholism
  • Neuroendocrine Effects

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

The alcohol clamp : Applications, challenges, and new directions - An RSA 2004 symposium summary. / Ramchandani, Vijay A.; O'Connor, Sean; Neumark, Yehuda; Zimmermann, Ulrich S.; Morzorati, Sandra; De Wit, Harriet.

In: Alcoholism: Clinical and Experimental Research, Vol. 30, No. 1, 01.2006, p. 155-164.

Research output: Contribution to journalArticle

Ramchandani, Vijay A. ; O'Connor, Sean ; Neumark, Yehuda ; Zimmermann, Ulrich S. ; Morzorati, Sandra ; De Wit, Harriet. / The alcohol clamp : Applications, challenges, and new directions - An RSA 2004 symposium summary. In: Alcoholism: Clinical and Experimental Research. 2006 ; Vol. 30, No. 1. pp. 155-164.
@article{c8e11794b0d4468d87f66f24391ad422,
title = "The alcohol clamp: Applications, challenges, and new directions - An RSA 2004 symposium summary",
abstract = "This article summarizes the proceedings of a symposium organized and cochaired by Vijay Ramchandani and Sean O'Connor and presented at the 2004 Research Society on Alcoholism meeting in Vancouver, BC, Canada. The objectives of this symposium were: (1) to provide a rationale for the development and use of the alcohol clamp and the requirements for its use in alcohol challenge studies; (2) to highlight recent studies conducted using the alcohol clamp to identify sources of variation in the pharmacokinetics and pharmacodynamics of alcohol, as well as to address important research questions related to the relationship between the response to alcohol and the risk for alcoholism; and (3) to provide a perspective on progress, address limitations of the clamp, and identify new directions for alcohol challenge research. The symposium began with an introduction and overview of the alcohol clamp, by Vijay Ramchandani. This was followed by 4 presentations that highlighted recent studies conducted using the clamp including: (1) determination of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in a male Jewish population, by Yehuda Neumark; (2) examination of family history of alcoholism, recent drinking history, and levels and rates of administration as determinants of the response to alcohol and risk for alcoholism, by Sean O'Connor; (3) evaluation of the time course of ethanol intoxication on neuroendocrine function in humans, by Ulrich Zimmermann; and (4) a study of the effects of steady-state blood alcohol levels on auditory event-related potentials in rats, by Sandra Morzorati. Harriet de Wit summarized and discussed the research presented at the symposium and provided her perspective on future directions for research using the alcohol clamp.",
keywords = "ADH, Alcohol Clamp, Alcohol Elimination Rate, Auditory Event-Related Potentials, Family History of Alcoholism, Neuroendocrine Effects",
author = "Ramchandani, {Vijay A.} and Sean O'Connor and Yehuda Neumark and Zimmermann, {Ulrich S.} and Sandra Morzorati and {De Wit}, Harriet",
year = "2006",
month = "1",
doi = "10.1111/j.1530-0277.2006.00017.x",
language = "English",
volume = "30",
pages = "155--164",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The alcohol clamp

T2 - Applications, challenges, and new directions - An RSA 2004 symposium summary

AU - Ramchandani, Vijay A.

AU - O'Connor, Sean

AU - Neumark, Yehuda

AU - Zimmermann, Ulrich S.

AU - Morzorati, Sandra

AU - De Wit, Harriet

PY - 2006/1

Y1 - 2006/1

N2 - This article summarizes the proceedings of a symposium organized and cochaired by Vijay Ramchandani and Sean O'Connor and presented at the 2004 Research Society on Alcoholism meeting in Vancouver, BC, Canada. The objectives of this symposium were: (1) to provide a rationale for the development and use of the alcohol clamp and the requirements for its use in alcohol challenge studies; (2) to highlight recent studies conducted using the alcohol clamp to identify sources of variation in the pharmacokinetics and pharmacodynamics of alcohol, as well as to address important research questions related to the relationship between the response to alcohol and the risk for alcoholism; and (3) to provide a perspective on progress, address limitations of the clamp, and identify new directions for alcohol challenge research. The symposium began with an introduction and overview of the alcohol clamp, by Vijay Ramchandani. This was followed by 4 presentations that highlighted recent studies conducted using the clamp including: (1) determination of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in a male Jewish population, by Yehuda Neumark; (2) examination of family history of alcoholism, recent drinking history, and levels and rates of administration as determinants of the response to alcohol and risk for alcoholism, by Sean O'Connor; (3) evaluation of the time course of ethanol intoxication on neuroendocrine function in humans, by Ulrich Zimmermann; and (4) a study of the effects of steady-state blood alcohol levels on auditory event-related potentials in rats, by Sandra Morzorati. Harriet de Wit summarized and discussed the research presented at the symposium and provided her perspective on future directions for research using the alcohol clamp.

AB - This article summarizes the proceedings of a symposium organized and cochaired by Vijay Ramchandani and Sean O'Connor and presented at the 2004 Research Society on Alcoholism meeting in Vancouver, BC, Canada. The objectives of this symposium were: (1) to provide a rationale for the development and use of the alcohol clamp and the requirements for its use in alcohol challenge studies; (2) to highlight recent studies conducted using the alcohol clamp to identify sources of variation in the pharmacokinetics and pharmacodynamics of alcohol, as well as to address important research questions related to the relationship between the response to alcohol and the risk for alcoholism; and (3) to provide a perspective on progress, address limitations of the clamp, and identify new directions for alcohol challenge research. The symposium began with an introduction and overview of the alcohol clamp, by Vijay Ramchandani. This was followed by 4 presentations that highlighted recent studies conducted using the clamp including: (1) determination of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in a male Jewish population, by Yehuda Neumark; (2) examination of family history of alcoholism, recent drinking history, and levels and rates of administration as determinants of the response to alcohol and risk for alcoholism, by Sean O'Connor; (3) evaluation of the time course of ethanol intoxication on neuroendocrine function in humans, by Ulrich Zimmermann; and (4) a study of the effects of steady-state blood alcohol levels on auditory event-related potentials in rats, by Sandra Morzorati. Harriet de Wit summarized and discussed the research presented at the symposium and provided her perspective on future directions for research using the alcohol clamp.

KW - ADH

KW - Alcohol Clamp

KW - Alcohol Elimination Rate

KW - Auditory Event-Related Potentials

KW - Family History of Alcoholism

KW - Neuroendocrine Effects

UR - http://www.scopus.com/inward/record.url?scp=33644757783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644757783&partnerID=8YFLogxK

U2 - 10.1111/j.1530-0277.2006.00017.x

DO - 10.1111/j.1530-0277.2006.00017.x

M3 - Article

C2 - 16433744

AN - SCOPUS:33644757783

VL - 30

SP - 155

EP - 164

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 1

ER -