The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, John C. Morris, Ronald C. Petersen, Jennifer Salazar, Andrew Saykin, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Introduction: The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI-3, which began on August 1, 2016, is a 5-year renewal of the current ADNI-2 study. Methods: ADNI-3 will follow current and additional subjects with normal cognition, mild cognitive impairment, and AD using innovative technologies such as tau imaging, magnetic resonance imaging sequences for connectivity analyses, and a highly automated immunoassay platform and mass spectroscopy approach for cerebrospinal fluid biomarker analysis. A Systems Biology/pathway approach will be used to identify genetic factors for subject selection/enrichment. Amyloid positron emission tomography scanning will be standardized using the Centiloid method. The Brain Health Registry will help recruit subjects and monitor subject cognition. Results: Multimodal analyses will provide insight into AD pathophysiology and disease progression. Discussion: ADNI-3 will aim to inform AD treatment trials and facilitate development of AD disease-modifying treatments.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

Fingerprint

Neuroimaging
Alzheimer Disease
Clinical Trials
Cognition
Biomarkers
Systems Biology
Immunoassay
Amyloid
Positron-Emission Tomography
Patient Selection
Sequence Analysis
Cerebrospinal Fluid
Registries
Disease Progression
Mass Spectrometry
Magnetic Resonance Imaging
Technology
Health
Brain

Keywords

  • Alzheimer's disease
  • Amyloid phenotyping
  • Brain Health Registry
  • Centiloid method
  • Clinical trial biomarkers
  • Functional connectivity
  • Tau imaging

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Green, R. C., ... Trojanowski, J. Q. (Accepted/In press). The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.10.006

The Alzheimer's Disease Neuroimaging Initiative 3 : Continued innovation for clinical trial improvement. / Weiner, Michael W.; Veitch, Dallas P.; Aisen, Paul S.; Beckett, Laurel A.; Cairns, Nigel J.; Green, Robert C.; Harvey, Danielle; Jack, Clifford R.; Jagust, William; Morris, John C.; Petersen, Ronald C.; Salazar, Jennifer; Saykin, Andrew; Shaw, Leslie M.; Toga, Arthur W.; Trojanowski, John Q.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

Weiner, MW, Veitch, DP, Aisen, PS, Beckett, LA, Cairns, NJ, Green, RC, Harvey, D, Jack, CR, Jagust, W, Morris, JC, Petersen, RC, Salazar, J, Saykin, A, Shaw, LM, Toga, AW & Trojanowski, JQ 2016, 'The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.10.006
Weiner, Michael W. ; Veitch, Dallas P. ; Aisen, Paul S. ; Beckett, Laurel A. ; Cairns, Nigel J. ; Green, Robert C. ; Harvey, Danielle ; Jack, Clifford R. ; Jagust, William ; Morris, John C. ; Petersen, Ronald C. ; Salazar, Jennifer ; Saykin, Andrew ; Shaw, Leslie M. ; Toga, Arthur W. ; Trojanowski, John Q. / The Alzheimer's Disease Neuroimaging Initiative 3 : Continued innovation for clinical trial improvement. In: Alzheimer's and Dementia. 2016.
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