The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods

Clifford R. Jack, Matt A. Bernstein, Nick C. Fox, Paul Thompson, Gene Alexander, Danielle Harvey, Bret Borowski, Paula J. Britson, Jennifer L. Whitwell, Chadwick Ward, Anders M. Dale, Joel P. Felmlee, Jeffrey L. Gunter, Derek L.G. Hill, Ron Killiany, Norbert Schuff, Sabrina Fox-Bosetti, Chen Lin, Colin Studholme, Charles S. DeCarliGunnar Krueger, Heidi A. Ward, Gregory J. Metzger, Katherine T. Scott, Richard Mallozzi, Daniel Blezek, Joshua Levy, Josef P. Debbins, Adam S. Fleisher, Marilyn Albert, Robert Green, George Bartzokis, Gary Glover, John Mugler, Michael W. Weiner

Research output: Contribution to journalReview article

1325 Scopus citations

Abstract

The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's disease. Magnetic resonance imaging (MRI), (18F)-fluorodeoxyglucose positron emission tomography (FDG PET), urine serum, and cerebrospinal fluid (CSF) biomarkers, as well as clinical/psychometric assessments are acquiredat multiple time points. All data will be cross-linked and made available to the general scientific community. The purpose of this report is to describe the MRI methods employed in ADNI. The ADNI MRI core established specifications thatguided protocol development. A major effort was devoted toevaluating 3D T1-weighted sequences for morphometric analyses. Several options for this sequence were optimized for the relevant manufacturer platforms and then compared in a reduced-scale clinical trial. The protocol selected for the ADNI study includes: back-to-back 3D magnetization prepared rapid gradient echo (MP-RAGE) scans; B1-calibration scans when applicable; and an axial proton density-T2 dual contrast (i.e., echo) fast spin echo/turbo spin echo (FSE/TSE) for pathology detection. ADNI MRI methods seek to maximize scientific utility while minimizing the burden placed on participants. The approach taken in ADNI to standardization across sites and platforms of the MRI protocol, postacquisition corrections, and phantom-based monitoring of all scanners could be used as a model for other multisite trials.

Original languageEnglish (US)
Pages (from-to)685-691
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2008

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Keywords

  • Alzheimer's disease
  • Clinical trials
  • Imaging methods
  • Imaging standardization
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Jack, C. R., Bernstein, M. A., Fox, N. C., Thompson, P., Alexander, G., Harvey, D., Borowski, B., Britson, P. J., Whitwell, J. L., Ward, C., Dale, A. M., Felmlee, J. P., Gunter, J. L., Hill, D. L. G., Killiany, R., Schuff, N., Fox-Bosetti, S., Lin, C., Studholme, C., ... Weiner, M. W. (2008). The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. Journal of Magnetic Resonance Imaging, 27(4), 685-691. https://doi.org/10.1002/jmri.21049