The apparent relation between plasma 25-hydroxyvitamin D and insulin resistance is largely attributable to central adiposity in overweight and obese adults

Christian S. Wright, Eileen M. Weinheimer-Haus, James C. Fleet, Munro Peacock, Wayne W. Campbell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Research indicates that plasma 25-hydroxyvitamin D [25(OH)D] is associated with insulin resistance, but whether regional adiposity confounds this association is unclear. Objective: This study assessed the potential influence of adiposity and its anatomical distribution on the relation between plasma 25(OH)D and insulin resistance. Methods: A secondary analysis of data from middle-aged overweight and obese healthy adults [n = 336: 213 women and 123 men; mean ± SD (range); age: 48 ± 8 y (35-65 y); body mass index (BMI; in kg/m2): 30.3 ± 2.7 (26-35)] from West Lafayette, Indiana (40.4°N), were used for this cross-sectional analysis. Multiple linear regression analyses that controlled for multiple covariates were used as the primary statistical model. Results: Of all participants, 8.6% and 20.5% displayed moderate [20.1-37.5 nmol/L plasma 25(OH)D] to mild (37.6-49.9 nmol/L) vitamin D insufficiency, respectively. A regression analysis controlling for age, sex, race, plasma parathyroid hormone concentration, season of year, and supplement use showed that 25(OH)D was negatively associated with fasting insulin (P = 0.021). Additional regression analyses showed that total and central adiposity but not peripheral adiposity predicted low plasma 25(OH)D [total fat mass index (FMI): P = 0.018; android FMI: P = 0.052; gynoid FMI: P = 0.15; appendicular FMI: P = 0.07) and insulin resistance (homeostasis model assessment of insulin resistance: total and android FMI, P

Original languageEnglish (US)
Pages (from-to)2683-2689
Number of pages7
JournalJournal of Nutrition
Volume145
Issue number12
DOIs
StatePublished - 2015

Fingerprint

Adiposity
Insulin Resistance
Fats
Regression Analysis
Statistical Models
Parathyroid Hormone
Vitamin D
Linear Models
Fasting
Body Mass Index
Homeostasis
Cross-Sectional Studies
25-hydroxyvitamin D
Insulin
Research

Keywords

  • 25(OH)D
  • Adiposity
  • Body composition
  • Central adiposity
  • Insulin resistance
  • Vitamin D status

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

The apparent relation between plasma 25-hydroxyvitamin D and insulin resistance is largely attributable to central adiposity in overweight and obese adults. / Wright, Christian S.; Weinheimer-Haus, Eileen M.; Fleet, James C.; Peacock, Munro; Campbell, Wayne W.

In: Journal of Nutrition, Vol. 145, No. 12, 2015, p. 2683-2689.

Research output: Contribution to journalArticle

Wright, Christian S. ; Weinheimer-Haus, Eileen M. ; Fleet, James C. ; Peacock, Munro ; Campbell, Wayne W. / The apparent relation between plasma 25-hydroxyvitamin D and insulin resistance is largely attributable to central adiposity in overweight and obese adults. In: Journal of Nutrition. 2015 ; Vol. 145, No. 12. pp. 2683-2689.
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N2 - Background: Research indicates that plasma 25-hydroxyvitamin D [25(OH)D] is associated with insulin resistance, but whether regional adiposity confounds this association is unclear. Objective: This study assessed the potential influence of adiposity and its anatomical distribution on the relation between plasma 25(OH)D and insulin resistance. Methods: A secondary analysis of data from middle-aged overweight and obese healthy adults [n = 336: 213 women and 123 men; mean ± SD (range); age: 48 ± 8 y (35-65 y); body mass index (BMI; in kg/m2): 30.3 ± 2.7 (26-35)] from West Lafayette, Indiana (40.4°N), were used for this cross-sectional analysis. Multiple linear regression analyses that controlled for multiple covariates were used as the primary statistical model. Results: Of all participants, 8.6% and 20.5% displayed moderate [20.1-37.5 nmol/L plasma 25(OH)D] to mild (37.6-49.9 nmol/L) vitamin D insufficiency, respectively. A regression analysis controlling for age, sex, race, plasma parathyroid hormone concentration, season of year, and supplement use showed that 25(OH)D was negatively associated with fasting insulin (P = 0.021). Additional regression analyses showed that total and central adiposity but not peripheral adiposity predicted low plasma 25(OH)D [total fat mass index (FMI): P = 0.018; android FMI: P = 0.052; gynoid FMI: P = 0.15; appendicular FMI: P = 0.07) and insulin resistance (homeostasis model assessment of insulin resistance: total and android FMI, P

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