The association between apo E genotype and depressive symptoms in elderly African-American subjects

C. Andrew Class, Frederick Unverzagt, Sujuan Gao, Amrik Sahota, Kathleen Hall, Hugh Hendrie

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16 Citations (Scopus)

Abstract

In this study of 138 elderly subjects (112 without and 26 with dementia) obtained from a community sample of elderly African- American subjects, there were no significant differences in mean Geriatric Depression Scale scores by Apo E ε4 status for dementia or nondementia subjects. Three subjects received a diagnosis of major depressive disorder. None of these subjects were Apo E ε4-positive. These results do not support an association between depressive symptoms and Apo E allele status in this elderly African-American population.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Volume5
Issue number4
DOIs
StatePublished - 1997

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Apolipoproteins E
African Americans
Apolipoprotein E4
Genotype
Depression
Dementia
Major Depressive Disorder
Geriatrics
Alleles
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

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AU - Unverzagt, Frederick

AU - Gao, Sujuan

AU - Sahota, Amrik

AU - Hall, Kathleen

AU - Hendrie, Hugh

PY - 1997

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AB - In this study of 138 elderly subjects (112 without and 26 with dementia) obtained from a community sample of elderly African- American subjects, there were no significant differences in mean Geriatric Depression Scale scores by Apo E ε4 status for dementia or nondementia subjects. Three subjects received a diagnosis of major depressive disorder. None of these subjects were Apo E ε4-positive. These results do not support an association between depressive symptoms and Apo E allele status in this elderly African-American population.

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