The association between cognition and histamine-2 receptor antagonists in African Americans

Malaz Boustani, Kathleen Hall, Kathleen A. Lane, Hisham Aljadhey, Sujuan Gao, Frederick Unverzagt, Michael Murray, Adesola Ogunniyi, Hugh Hendrie

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

OBJECTIVES: To evaluate the association between histamine-2 receptor antagonist (H2A) exposure and incident cognitive impairment in a community-based sample of African Americans. DESIGN: Five-year longitudinal observational study. PARTICIPANTS: A sample of 1,558 community-dwelling African Americans aged 65 and older with no baseline cognitive impairment living in Indianapolis, Indiana. OUTCOME MEASURE: Incident cognitive impairment, defined as incident dementia, cognitive impairment without dementia, or poor cognitive performance, as determined using combined cognitive assessments that included the Community Screening Instrument for Dementia, a comprehensive clinical assessment including informant interview, and neuropsychological testing. EXPOSURE: Trained interviewers assessed the use of prescription and over-the-counter H2As using in-home inspection of medications and report of participants and informants. RESULTS: Incident cognitive impairment occurred in 275 (17.7%) participants. After controlling for age, education, baseline cognitive score, the use of anticholinergics, and history of diabetes mellitus and depression, continuous use of H2As was associated with greater risk of incident cognitive impairment than for nonusers (odds ratio=2.42; 95% confidence interval=1.17-5.04). CONCLUSION: H2As might be a risk factor for the development of cognitive impairment in African Americans. This finding requires confirmation from future studies.

Original languageEnglish
Pages (from-to)1248-1253
Number of pages6
JournalJournal of the American Geriatrics Society
Volume55
Issue number8
DOIs
StatePublished - Aug 2007

Fingerprint

Histamine Receptors
African Americans
Cognition
Dementia
Interviews
Independent Living
Cholinergic Antagonists
Cognitive Dysfunction
Observational Studies
Prescriptions
Longitudinal Studies
Diabetes Mellitus
Odds Ratio
Confidence Intervals
Depression
Education

Keywords

  • Cognitive impairment
  • Histamine antagonists
  • Risk factor

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

The association between cognition and histamine-2 receptor antagonists in African Americans. / Boustani, Malaz; Hall, Kathleen; Lane, Kathleen A.; Aljadhey, Hisham; Gao, Sujuan; Unverzagt, Frederick; Murray, Michael; Ogunniyi, Adesola; Hendrie, Hugh.

In: Journal of the American Geriatrics Society, Vol. 55, No. 8, 08.2007, p. 1248-1253.

Research output: Contribution to journalArticle

@article{0e328334cecb41fcbe6ab3e0ba3ba9de,
title = "The association between cognition and histamine-2 receptor antagonists in African Americans",
abstract = "OBJECTIVES: To evaluate the association between histamine-2 receptor antagonist (H2A) exposure and incident cognitive impairment in a community-based sample of African Americans. DESIGN: Five-year longitudinal observational study. PARTICIPANTS: A sample of 1,558 community-dwelling African Americans aged 65 and older with no baseline cognitive impairment living in Indianapolis, Indiana. OUTCOME MEASURE: Incident cognitive impairment, defined as incident dementia, cognitive impairment without dementia, or poor cognitive performance, as determined using combined cognitive assessments that included the Community Screening Instrument for Dementia, a comprehensive clinical assessment including informant interview, and neuropsychological testing. EXPOSURE: Trained interviewers assessed the use of prescription and over-the-counter H2As using in-home inspection of medications and report of participants and informants. RESULTS: Incident cognitive impairment occurred in 275 (17.7{\%}) participants. After controlling for age, education, baseline cognitive score, the use of anticholinergics, and history of diabetes mellitus and depression, continuous use of H2As was associated with greater risk of incident cognitive impairment than for nonusers (odds ratio=2.42; 95{\%} confidence interval=1.17-5.04). CONCLUSION: H2As might be a risk factor for the development of cognitive impairment in African Americans. This finding requires confirmation from future studies.",
keywords = "Cognitive impairment, Histamine antagonists, Risk factor",
author = "Malaz Boustani and Kathleen Hall and Lane, {Kathleen A.} and Hisham Aljadhey and Sujuan Gao and Frederick Unverzagt and Michael Murray and Adesola Ogunniyi and Hugh Hendrie",
year = "2007",
month = "8",
doi = "10.1111/j.1532-5415.2007.01270.x",
language = "English",
volume = "55",
pages = "1248--1253",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - The association between cognition and histamine-2 receptor antagonists in African Americans

AU - Boustani, Malaz

AU - Hall, Kathleen

AU - Lane, Kathleen A.

AU - Aljadhey, Hisham

AU - Gao, Sujuan

AU - Unverzagt, Frederick

AU - Murray, Michael

AU - Ogunniyi, Adesola

AU - Hendrie, Hugh

PY - 2007/8

Y1 - 2007/8

N2 - OBJECTIVES: To evaluate the association between histamine-2 receptor antagonist (H2A) exposure and incident cognitive impairment in a community-based sample of African Americans. DESIGN: Five-year longitudinal observational study. PARTICIPANTS: A sample of 1,558 community-dwelling African Americans aged 65 and older with no baseline cognitive impairment living in Indianapolis, Indiana. OUTCOME MEASURE: Incident cognitive impairment, defined as incident dementia, cognitive impairment without dementia, or poor cognitive performance, as determined using combined cognitive assessments that included the Community Screening Instrument for Dementia, a comprehensive clinical assessment including informant interview, and neuropsychological testing. EXPOSURE: Trained interviewers assessed the use of prescription and over-the-counter H2As using in-home inspection of medications and report of participants and informants. RESULTS: Incident cognitive impairment occurred in 275 (17.7%) participants. After controlling for age, education, baseline cognitive score, the use of anticholinergics, and history of diabetes mellitus and depression, continuous use of H2As was associated with greater risk of incident cognitive impairment than for nonusers (odds ratio=2.42; 95% confidence interval=1.17-5.04). CONCLUSION: H2As might be a risk factor for the development of cognitive impairment in African Americans. This finding requires confirmation from future studies.

AB - OBJECTIVES: To evaluate the association between histamine-2 receptor antagonist (H2A) exposure and incident cognitive impairment in a community-based sample of African Americans. DESIGN: Five-year longitudinal observational study. PARTICIPANTS: A sample of 1,558 community-dwelling African Americans aged 65 and older with no baseline cognitive impairment living in Indianapolis, Indiana. OUTCOME MEASURE: Incident cognitive impairment, defined as incident dementia, cognitive impairment without dementia, or poor cognitive performance, as determined using combined cognitive assessments that included the Community Screening Instrument for Dementia, a comprehensive clinical assessment including informant interview, and neuropsychological testing. EXPOSURE: Trained interviewers assessed the use of prescription and over-the-counter H2As using in-home inspection of medications and report of participants and informants. RESULTS: Incident cognitive impairment occurred in 275 (17.7%) participants. After controlling for age, education, baseline cognitive score, the use of anticholinergics, and history of diabetes mellitus and depression, continuous use of H2As was associated with greater risk of incident cognitive impairment than for nonusers (odds ratio=2.42; 95% confidence interval=1.17-5.04). CONCLUSION: H2As might be a risk factor for the development of cognitive impairment in African Americans. This finding requires confirmation from future studies.

KW - Cognitive impairment

KW - Histamine antagonists

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=34547133717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547133717&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2007.01270.x

DO - 10.1111/j.1532-5415.2007.01270.x

M3 - Article

C2 - 17661965

AN - SCOPUS:34547133717

VL - 55

SP - 1248

EP - 1253

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 8

ER -