The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer

Timothy Masterson, Fernando J. Bianco, Andrew J. Vickers, Christopher J. Diblasio, Paul A. Fearn, Farhang Rabbani, James A. Eastham, Peter T. Scardino

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Purpose: We examined the association between the number of LNs removed, the number of positive LNs and disease progression in patients undergoing pelvic lymph node dissection and radical retropubic prostatectomy for clinically localized prostate cancer. Materials and Methods: We analyzed 5,038 consecutive patients who underwent radical retropubic prostatectomy between 1983 and 2003. Clinicopathological parameters, including the administration of neoadjuvant hormonal therapy, preoperative prostate specific antigen, specimen Gleason score, surgeon and pathological stage, were collected prospectively in our prostate cancer database. We excluded men treated with radiation or chemotherapy before surgery. BCR was defined as 2 postoperative prostate specific antigen increases greater than 0.2 ng/ml. Cox models were used to determine whether the number of nodes removed or the number of positive nodes predicted freedom from BCR after adjustment for prognostic covariates. Results: The 4,611 eligible patients had a median of 9 LNs (IQR 5 to 13) removed. Positive nodes were found in 175 patients (3.8%). Overall the number of LNs removed did not predict freedom from BCR (HR per additional 10 nodes removed 1.02, 95% CI 0.92 to 1.13, p = 0.7). Results were similar in patients receiving and not receiving neoadjuvant hormonal therapy. Finding any LN involvement was associated with a BCR HR of 5.2 (95% CI 4.2 to 6.4, p

Original languageEnglish (US)
Pages (from-to)1320-1324
Number of pages5
JournalJournal of Urology
Volume175
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Disease Progression
Prostatic Neoplasms
Lymph Nodes
Neoadjuvant Therapy
Prostate-Specific Antigen
Prostatectomy
Neoplasm Grading
Lymph Node Excision
Proportional Hazards Models
Databases
Radiation
Drug Therapy

Keywords

  • Local
  • Lymph node excision
  • Lymph nodes
  • Neoplasm recurrence
  • Prostate
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer. / Masterson, Timothy; Bianco, Fernando J.; Vickers, Andrew J.; Diblasio, Christopher J.; Fearn, Paul A.; Rabbani, Farhang; Eastham, James A.; Scardino, Peter T.

In: Journal of Urology, Vol. 175, No. 4, 04.2006, p. 1320-1324.

Research output: Contribution to journalArticle

Masterson, T, Bianco, FJ, Vickers, AJ, Diblasio, CJ, Fearn, PA, Rabbani, F, Eastham, JA & Scardino, PT 2006, 'The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer', Journal of Urology, vol. 175, no. 4, pp. 1320-1324. https://doi.org/10.1016/S0022-5347(05)00685-3
Masterson, Timothy ; Bianco, Fernando J. ; Vickers, Andrew J. ; Diblasio, Christopher J. ; Fearn, Paul A. ; Rabbani, Farhang ; Eastham, James A. ; Scardino, Peter T. / The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer. In: Journal of Urology. 2006 ; Vol. 175, No. 4. pp. 1320-1324.
@article{508372e3d8fa418ba58399d80634833a,
title = "The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer",
abstract = "Purpose: We examined the association between the number of LNs removed, the number of positive LNs and disease progression in patients undergoing pelvic lymph node dissection and radical retropubic prostatectomy for clinically localized prostate cancer. Materials and Methods: We analyzed 5,038 consecutive patients who underwent radical retropubic prostatectomy between 1983 and 2003. Clinicopathological parameters, including the administration of neoadjuvant hormonal therapy, preoperative prostate specific antigen, specimen Gleason score, surgeon and pathological stage, were collected prospectively in our prostate cancer database. We excluded men treated with radiation or chemotherapy before surgery. BCR was defined as 2 postoperative prostate specific antigen increases greater than 0.2 ng/ml. Cox models were used to determine whether the number of nodes removed or the number of positive nodes predicted freedom from BCR after adjustment for prognostic covariates. Results: The 4,611 eligible patients had a median of 9 LNs (IQR 5 to 13) removed. Positive nodes were found in 175 patients (3.8{\%}). Overall the number of LNs removed did not predict freedom from BCR (HR per additional 10 nodes removed 1.02, 95{\%} CI 0.92 to 1.13, p = 0.7). Results were similar in patients receiving and not receiving neoadjuvant hormonal therapy. Finding any LN involvement was associated with a BCR HR of 5.2 (95{\%} CI 4.2 to 6.4, p",
keywords = "Local, Lymph node excision, Lymph nodes, Neoplasm recurrence, Prostate, Prostatic neoplasms",
author = "Timothy Masterson and Bianco, {Fernando J.} and Vickers, {Andrew J.} and Diblasio, {Christopher J.} and Fearn, {Paul A.} and Farhang Rabbani and Eastham, {James A.} and Scardino, {Peter T.}",
year = "2006",
month = "4",
doi = "10.1016/S0022-5347(05)00685-3",
language = "English (US)",
volume = "175",
pages = "1320--1324",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer

AU - Masterson, Timothy

AU - Bianco, Fernando J.

AU - Vickers, Andrew J.

AU - Diblasio, Christopher J.

AU - Fearn, Paul A.

AU - Rabbani, Farhang

AU - Eastham, James A.

AU - Scardino, Peter T.

PY - 2006/4

Y1 - 2006/4

N2 - Purpose: We examined the association between the number of LNs removed, the number of positive LNs and disease progression in patients undergoing pelvic lymph node dissection and radical retropubic prostatectomy for clinically localized prostate cancer. Materials and Methods: We analyzed 5,038 consecutive patients who underwent radical retropubic prostatectomy between 1983 and 2003. Clinicopathological parameters, including the administration of neoadjuvant hormonal therapy, preoperative prostate specific antigen, specimen Gleason score, surgeon and pathological stage, were collected prospectively in our prostate cancer database. We excluded men treated with radiation or chemotherapy before surgery. BCR was defined as 2 postoperative prostate specific antigen increases greater than 0.2 ng/ml. Cox models were used to determine whether the number of nodes removed or the number of positive nodes predicted freedom from BCR after adjustment for prognostic covariates. Results: The 4,611 eligible patients had a median of 9 LNs (IQR 5 to 13) removed. Positive nodes were found in 175 patients (3.8%). Overall the number of LNs removed did not predict freedom from BCR (HR per additional 10 nodes removed 1.02, 95% CI 0.92 to 1.13, p = 0.7). Results were similar in patients receiving and not receiving neoadjuvant hormonal therapy. Finding any LN involvement was associated with a BCR HR of 5.2 (95% CI 4.2 to 6.4, p

AB - Purpose: We examined the association between the number of LNs removed, the number of positive LNs and disease progression in patients undergoing pelvic lymph node dissection and radical retropubic prostatectomy for clinically localized prostate cancer. Materials and Methods: We analyzed 5,038 consecutive patients who underwent radical retropubic prostatectomy between 1983 and 2003. Clinicopathological parameters, including the administration of neoadjuvant hormonal therapy, preoperative prostate specific antigen, specimen Gleason score, surgeon and pathological stage, were collected prospectively in our prostate cancer database. We excluded men treated with radiation or chemotherapy before surgery. BCR was defined as 2 postoperative prostate specific antigen increases greater than 0.2 ng/ml. Cox models were used to determine whether the number of nodes removed or the number of positive nodes predicted freedom from BCR after adjustment for prognostic covariates. Results: The 4,611 eligible patients had a median of 9 LNs (IQR 5 to 13) removed. Positive nodes were found in 175 patients (3.8%). Overall the number of LNs removed did not predict freedom from BCR (HR per additional 10 nodes removed 1.02, 95% CI 0.92 to 1.13, p = 0.7). Results were similar in patients receiving and not receiving neoadjuvant hormonal therapy. Finding any LN involvement was associated with a BCR HR of 5.2 (95% CI 4.2 to 6.4, p

KW - Local

KW - Lymph node excision

KW - Lymph nodes

KW - Neoplasm recurrence

KW - Prostate

KW - Prostatic neoplasms

UR - http://www.scopus.com/inward/record.url?scp=33644605439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644605439&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(05)00685-3

DO - 10.1016/S0022-5347(05)00685-3

M3 - Article

VL - 175

SP - 1320

EP - 1324

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 4

ER -