The Association of Early Life Factors and Declining Incidence Rates of Dementia in an Elderly Population of African Americans

Hugh Hendrie, Valerie Smith-Gamble, Kathleen A. Lane, Christianna Purnell, Daniel Clark, Sujuan Gao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To explore the possible association of childhood residence, education levels, and occupation with declining incidence rates of dementia in 2 cohorts of elderly African Americans. Methods African Americans residing in Indianapolis without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years. The cohorts consist of 1,440 participants in 1992 and 1,835 participants in 2001 aged 70 years and older. Cox proportional hazard regression models were used to compare cohort differences in dementia and Alzheimer's disease (AD) risk. Results The 2001 cohort had significantly decreased risk of both incident dementia and AD (hazard ratio [HR]: 0.62/0.57 for dementia/AD). Years of education was associated with decreased risk of dementia (HR = 0.93; p =.0011). A significant interaction (p =.0477) between education and childhood rural residence was found for the risk of AD that higher education level is significantly associated with reduced AD risk (HR = 0.87) in participants with childhood rural residence, but no association in those with urban upbringing. The cohort difference for dementia rates were attenuated by adjusting for the 3 risk factors but remained significant (HR = 0.75; p =.04). Discussion These results emphasize the importance of early life factors including rural residence and education for the risk for dementia later in life.

Original languageEnglish (US)
Pages (from-to)S82-S90
JournalJournals of Gerontology - Series B Psychological Sciences and Social Sciences
Volume73
DOIs
StatePublished - Apr 16 2018

Fingerprint

dementia
African Americans
Dementia
incidence
Incidence
Alzheimer Disease
Population
Education
childhood
education
American
Occupations
Proportional Hazards Models
Odds Ratio
incident
occupation

Keywords

  • Alzheimer's disease
  • Education
  • Employment
  • Rural-Urban

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Clinical Psychology
  • Sociology and Political Science
  • Gerontology
  • Geriatrics and Gerontology
  • Life-span and Life-course Studies

Cite this

@article{961c6276c83d44a9b925ee26464a0809,
title = "The Association of Early Life Factors and Declining Incidence Rates of Dementia in an Elderly Population of African Americans",
abstract = "Objectives: To explore the possible association of childhood residence, education levels, and occupation with declining incidence rates of dementia in 2 cohorts of elderly African Americans. Methods African Americans residing in Indianapolis without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years. The cohorts consist of 1,440 participants in 1992 and 1,835 participants in 2001 aged 70 years and older. Cox proportional hazard regression models were used to compare cohort differences in dementia and Alzheimer's disease (AD) risk. Results The 2001 cohort had significantly decreased risk of both incident dementia and AD (hazard ratio [HR]: 0.62/0.57 for dementia/AD). Years of education was associated with decreased risk of dementia (HR = 0.93; p =.0011). A significant interaction (p =.0477) between education and childhood rural residence was found for the risk of AD that higher education level is significantly associated with reduced AD risk (HR = 0.87) in participants with childhood rural residence, but no association in those with urban upbringing. The cohort difference for dementia rates were attenuated by adjusting for the 3 risk factors but remained significant (HR = 0.75; p =.04). Discussion These results emphasize the importance of early life factors including rural residence and education for the risk for dementia later in life.",
keywords = "Alzheimer's disease, Education, Employment, Rural-Urban",
author = "Hugh Hendrie and Valerie Smith-Gamble and Lane, {Kathleen A.} and Christianna Purnell and Daniel Clark and Sujuan Gao",
year = "2018",
month = "4",
day = "16",
doi = "10.1093/geronb/gbx143",
language = "English (US)",
volume = "73",
pages = "S82--S90",
journal = "Journals of Gerontology - Series B Psychological Sciences and Social Sciences",
issn = "1079-5014",
publisher = "Gerontological Society of America",

}

TY - JOUR

T1 - The Association of Early Life Factors and Declining Incidence Rates of Dementia in an Elderly Population of African Americans

AU - Hendrie, Hugh

AU - Smith-Gamble, Valerie

AU - Lane, Kathleen A.

AU - Purnell, Christianna

AU - Clark, Daniel

AU - Gao, Sujuan

PY - 2018/4/16

Y1 - 2018/4/16

N2 - Objectives: To explore the possible association of childhood residence, education levels, and occupation with declining incidence rates of dementia in 2 cohorts of elderly African Americans. Methods African Americans residing in Indianapolis without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years. The cohorts consist of 1,440 participants in 1992 and 1,835 participants in 2001 aged 70 years and older. Cox proportional hazard regression models were used to compare cohort differences in dementia and Alzheimer's disease (AD) risk. Results The 2001 cohort had significantly decreased risk of both incident dementia and AD (hazard ratio [HR]: 0.62/0.57 for dementia/AD). Years of education was associated with decreased risk of dementia (HR = 0.93; p =.0011). A significant interaction (p =.0477) between education and childhood rural residence was found for the risk of AD that higher education level is significantly associated with reduced AD risk (HR = 0.87) in participants with childhood rural residence, but no association in those with urban upbringing. The cohort difference for dementia rates were attenuated by adjusting for the 3 risk factors but remained significant (HR = 0.75; p =.04). Discussion These results emphasize the importance of early life factors including rural residence and education for the risk for dementia later in life.

AB - Objectives: To explore the possible association of childhood residence, education levels, and occupation with declining incidence rates of dementia in 2 cohorts of elderly African Americans. Methods African Americans residing in Indianapolis without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years. The cohorts consist of 1,440 participants in 1992 and 1,835 participants in 2001 aged 70 years and older. Cox proportional hazard regression models were used to compare cohort differences in dementia and Alzheimer's disease (AD) risk. Results The 2001 cohort had significantly decreased risk of both incident dementia and AD (hazard ratio [HR]: 0.62/0.57 for dementia/AD). Years of education was associated with decreased risk of dementia (HR = 0.93; p =.0011). A significant interaction (p =.0477) between education and childhood rural residence was found for the risk of AD that higher education level is significantly associated with reduced AD risk (HR = 0.87) in participants with childhood rural residence, but no association in those with urban upbringing. The cohort difference for dementia rates were attenuated by adjusting for the 3 risk factors but remained significant (HR = 0.75; p =.04). Discussion These results emphasize the importance of early life factors including rural residence and education for the risk for dementia later in life.

KW - Alzheimer's disease

KW - Education

KW - Employment

KW - Rural-Urban

UR - http://www.scopus.com/inward/record.url?scp=85047943236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047943236&partnerID=8YFLogxK

U2 - 10.1093/geronb/gbx143

DO - 10.1093/geronb/gbx143

M3 - Article

C2 - 29669098

AN - SCOPUS:85047943236

VL - 73

SP - S82-S90

JO - Journals of Gerontology - Series B Psychological Sciences and Social Sciences

JF - Journals of Gerontology - Series B Psychological Sciences and Social Sciences

SN - 1079-5014

ER -