The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases

Jose Bonnin, L. J. Rubinstein, N. F. Palmer, J. B. Beckwith

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

This report documents, in 7 infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in 6 patients and a Wilms' tumor in 1) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included 3 cerebellar medulloblastomas, 1 pineoblastoma, 1 primitive neuroepithelial tumor (probably cerebral neuroblastoma), 1 malignant subependymal giant cell astrocytoma, and 1 cerebellar medulloepithelioma with divergent glial and neuronal differentiation. There is no evidence that this association is based on the selective neoplastic transformation of embryonal cells of similar histogenetic or cytogenetic origin. The relationship between these dissimilar, embryologically unrelated tumors remains enigmatic.

Original languageEnglish (US)
Pages (from-to)2137-2146
Number of pages10
JournalCancer
Volume54
Issue number10
StatePublished - 1984
Externally publishedYes

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Primitive Neuroectodermal Tumors
Neoplastic Cell Transformation
Rhabdoid Tumor
Neuroepithelial Neoplasms
Pinealoma
Kidney
Medulloblastoma
Wilms Tumor
Kidney Neoplasms
Germ Cell and Embryonal Neoplasms
Astrocytoma
Brain
Neuroblastoma
Cytogenetics
Neuroglia
Neoplasms
Central Nervous System

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bonnin, J., Rubinstein, L. J., Palmer, N. F., & Beckwith, J. B. (1984). The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases. Cancer, 54(10), 2137-2146.

The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases. / Bonnin, Jose; Rubinstein, L. J.; Palmer, N. F.; Beckwith, J. B.

In: Cancer, Vol. 54, No. 10, 1984, p. 2137-2146.

Research output: Contribution to journalArticle

Bonnin, J, Rubinstein, LJ, Palmer, NF & Beckwith, JB 1984, 'The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases', Cancer, vol. 54, no. 10, pp. 2137-2146.
Bonnin, Jose ; Rubinstein, L. J. ; Palmer, N. F. ; Beckwith, J. B. / The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases. In: Cancer. 1984 ; Vol. 54, No. 10. pp. 2137-2146.
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