The association of MRI findings and neuropsychological functioning after the first recognized seizure

Anna W. Byars, Ton J. Degrauw, Cynthia S. Johnson, Philip S. Fastenau, Susan Perkins, John C. Egelhoff, Andrew Kalnin, David Dunn, Joan K. Austin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Purpose: To explore relationships between MRI abnormalities of the brain and neuropsychological functioning in children who were evaluated following their first recognized seizure. Methods: Subjects were children aged 6 to 14 years with a first recognized seizure within the past 3 months who participated in a larger prospective study of child adaptation. The 249 children with neuropsychological testing and neuroimaging were studied. Children underwent neuropsychological examination an average of 2.8 months and MRI examination an average of 1.3 months after the first recognized seizure. On factor analysis four factors were found for neuropsychological function: LANG = Language, PS = Processing Speed, EC = Executive/ Construction, VMEM = Verbal Memory and Learning. For analysis, structural abnormalities found on MRI were classified as significant (yes/no) based on whether they were presumed to be related to the seizure condition. Results: On MRI, 34 (14%) had structural abnormalities that were judged to be significant in that they were possibly related to their seizures. Children with significant abnormalities had significantly lower estimated IQ scores and significantly lower language, processing speed, executive/constructional ability, and verbal memory and learning factor scores than did children without significant abnormalities. Conclusions: Children who have structural brain abnormalities at onset have slightly lower cognitive functioning overall, and all neuropsychological domains seemed to be affected relatively equally. This pattern was apparent even when we restricted the analysis to children with intellectual functioning in the broadly normal range.

Original languageEnglish
Pages (from-to)1067-1074
Number of pages8
JournalEpilepsia
Volume48
Issue number6
DOIs
StatePublished - Jun 2007

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Seizures
Verbal Learning
Language
Aptitude
Brain
Neuroimaging
Statistical Factor Analysis
Reference Values
Prospective Studies

Keywords

  • Child
  • Cognition
  • Epilepsy
  • Neuroimaging
  • Neuropsychological tests
  • Seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Byars, A. W., Degrauw, T. J., Johnson, C. S., Fastenau, P. S., Perkins, S., Egelhoff, J. C., ... Austin, J. K. (2007). The association of MRI findings and neuropsychological functioning after the first recognized seizure. Epilepsia, 48(6), 1067-1074. https://doi.org/10.1111/j.1528-1167.2007.01088.x

The association of MRI findings and neuropsychological functioning after the first recognized seizure. / Byars, Anna W.; Degrauw, Ton J.; Johnson, Cynthia S.; Fastenau, Philip S.; Perkins, Susan; Egelhoff, John C.; Kalnin, Andrew; Dunn, David; Austin, Joan K.

In: Epilepsia, Vol. 48, No. 6, 06.2007, p. 1067-1074.

Research output: Contribution to journalArticle

Byars, AW, Degrauw, TJ, Johnson, CS, Fastenau, PS, Perkins, S, Egelhoff, JC, Kalnin, A, Dunn, D & Austin, JK 2007, 'The association of MRI findings and neuropsychological functioning after the first recognized seizure', Epilepsia, vol. 48, no. 6, pp. 1067-1074. https://doi.org/10.1111/j.1528-1167.2007.01088.x
Byars, Anna W. ; Degrauw, Ton J. ; Johnson, Cynthia S. ; Fastenau, Philip S. ; Perkins, Susan ; Egelhoff, John C. ; Kalnin, Andrew ; Dunn, David ; Austin, Joan K. / The association of MRI findings and neuropsychological functioning after the first recognized seizure. In: Epilepsia. 2007 ; Vol. 48, No. 6. pp. 1067-1074.
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