The atypical antipsychotic drug amperozide enhances rat cortical and striatal dopamine efflux

Elizabeth A. Pehek, Herbert Y. Meltzer, Bryan Yamamoto

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Previous behavioral, biochemical, and electrophysiological studies have indicated that amperozide, a putative atypical antipsychotic drug with potent 5-HT2 receptor antagonist potency, preferentially affects mesocorticolimbic, as compared to mesostriatal dopamine neurons. The present experiment utilized in vivo microdialysis to compare the effects of amperozide on dopamine efflux in medial prefrontal cortex versus caudate-putamen in the freely moving rat. The results demonstrated that amperozide produced a greater elevation of cortical dopamine. These results were similar to those observed with clozapine but not haloperidol.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalEuropean Journal of Pharmacology
Volume240
Issue number1
DOIs
StatePublished - Aug 10 1993
Externally publishedYes

Fingerprint

Corpus Striatum
Antipsychotic Agents
Dopamine
Serotonin 5-HT2 Receptor Antagonists
Clozapine
Dopaminergic Neurons
Putamen
Microdialysis
Haloperidol
Prefrontal Cortex
amperozide

Keywords

  • Amperozide
  • Clozapine
  • Dopamine
  • Microdialysis
  • Prefrontal cortex
  • Schizophrenia

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The atypical antipsychotic drug amperozide enhances rat cortical and striatal dopamine efflux. / Pehek, Elizabeth A.; Meltzer, Herbert Y.; Yamamoto, Bryan.

In: European Journal of Pharmacology, Vol. 240, No. 1, 10.08.1993, p. 107-109.

Research output: Contribution to journalArticle

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