The basal ganglia as a substrate for the multiple actions of amphetamines

Reka Natarajan, Bryan K. Yamamoto

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Amphetamines are psychostimulant drugs with high abuse potential. Acute and chronic doses of amphetamines affect dopamine (DA) neurotransmission in the basal ganglia. The basal ganglia are a group of subcortical nuclei that are anatomically positioned to integrate cognitive, motor and sensorimotor inputs from the cortex. Amphetamines can differentially alter the functioning of specific BG circuits to produce neurochemical changes that affect cognition, movement, and drug seeking behavior through their effects on DA neurotransmission. This review focuses on how alterations in dopaminergic neurotransmission within distinct basal ganglia pathways can modify their functional output to predict and explain the acute and long term behavioral consequences of amphetamine exposure.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalBasal Ganglia
Volume1
Issue number2
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Addiction
  • Amphetamines
  • Basal ganglia
  • Drug abuse
  • Methamphetamine
  • Striatum

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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