The biological role and clinical implications of IgA

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The total body pool of human IgA (3,600-9,100 mg) is larger than that for all other isotypes combined. Most IgA resides in the small and large intestines in the form of polymeric or secretory IgA (sIgA). Serum IgA is primarily monomeric and comprises the second highest concentration of any immunoglobulin in the circulation. IgA is composed of two subclasses: IgA1 and IgA2. Secretory IgA consists of approximately equal amounts of IgA1 and IgA2. Serum IgA is predominantly IgA1 (90%). Secretory IgA functions to neutralize toxins, enzymes, and viruses; agglutinate pathogens; inhibit penetration of foreign antigen into the mucosa and attachment; activate the alternate complement pathway; and possibly opsonize pathogens. Secretory IgA is the first line of defense against most infectious agents, and the integrity of the sIgA system is important to the health of the individual. The biological role and clinical implications of IgA are discussed.

Original languageEnglish
Pages (from-to)724-728
Number of pages5
JournalLaboratory Medicine
Volume25
Issue number11
StatePublished - 1994

Fingerprint

Immunoglobulin A
Secretory Immunoglobulin A
Pathogens
Large Intestine
Serum
Viruses
Human Body
Small Intestine
Immunoglobulins
Mucous Membrane
Health
Antigens
Enzymes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Pathology and Forensic Medicine

Cite this

The biological role and clinical implications of IgA. / Gregory, Richard.

In: Laboratory Medicine, Vol. 25, No. 11, 1994, p. 724-728.

Research output: Contribution to journalArticle

@article{046c3f4ec0bf43eb876ee41c0a943cad,
title = "The biological role and clinical implications of IgA",
abstract = "The total body pool of human IgA (3,600-9,100 mg) is larger than that for all other isotypes combined. Most IgA resides in the small and large intestines in the form of polymeric or secretory IgA (sIgA). Serum IgA is primarily monomeric and comprises the second highest concentration of any immunoglobulin in the circulation. IgA is composed of two subclasses: IgA1 and IgA2. Secretory IgA consists of approximately equal amounts of IgA1 and IgA2. Serum IgA is predominantly IgA1 (90{\%}). Secretory IgA functions to neutralize toxins, enzymes, and viruses; agglutinate pathogens; inhibit penetration of foreign antigen into the mucosa and attachment; activate the alternate complement pathway; and possibly opsonize pathogens. Secretory IgA is the first line of defense against most infectious agents, and the integrity of the sIgA system is important to the health of the individual. The biological role and clinical implications of IgA are discussed.",
author = "Richard Gregory",
year = "1994",
language = "English",
volume = "25",
pages = "724--728",
journal = "Laboratory Medicine",
issn = "0007-5027",
publisher = "American Society of Clinical Pathologists",
number = "11",

}

TY - JOUR

T1 - The biological role and clinical implications of IgA

AU - Gregory, Richard

PY - 1994

Y1 - 1994

N2 - The total body pool of human IgA (3,600-9,100 mg) is larger than that for all other isotypes combined. Most IgA resides in the small and large intestines in the form of polymeric or secretory IgA (sIgA). Serum IgA is primarily monomeric and comprises the second highest concentration of any immunoglobulin in the circulation. IgA is composed of two subclasses: IgA1 and IgA2. Secretory IgA consists of approximately equal amounts of IgA1 and IgA2. Serum IgA is predominantly IgA1 (90%). Secretory IgA functions to neutralize toxins, enzymes, and viruses; agglutinate pathogens; inhibit penetration of foreign antigen into the mucosa and attachment; activate the alternate complement pathway; and possibly opsonize pathogens. Secretory IgA is the first line of defense against most infectious agents, and the integrity of the sIgA system is important to the health of the individual. The biological role and clinical implications of IgA are discussed.

AB - The total body pool of human IgA (3,600-9,100 mg) is larger than that for all other isotypes combined. Most IgA resides in the small and large intestines in the form of polymeric or secretory IgA (sIgA). Serum IgA is primarily monomeric and comprises the second highest concentration of any immunoglobulin in the circulation. IgA is composed of two subclasses: IgA1 and IgA2. Secretory IgA consists of approximately equal amounts of IgA1 and IgA2. Serum IgA is predominantly IgA1 (90%). Secretory IgA functions to neutralize toxins, enzymes, and viruses; agglutinate pathogens; inhibit penetration of foreign antigen into the mucosa and attachment; activate the alternate complement pathway; and possibly opsonize pathogens. Secretory IgA is the first line of defense against most infectious agents, and the integrity of the sIgA system is important to the health of the individual. The biological role and clinical implications of IgA are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0028027429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028027429&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028027429

VL - 25

SP - 724

EP - 728

JO - Laboratory Medicine

JF - Laboratory Medicine

SN - 0007-5027

IS - 11

ER -