The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid

Stephen B. Mason, Xianyin Lai, Robert L. Bacallao, Bonnie L. Biazer-Yost, Vincent H. Gattone, Kevin C. Wang, Frank A. Witzmann

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid-filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow-up experiment, we hypothesized that the protein-bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.

Original languageEnglish (US)
Pages (from-to)1247-1250
Number of pages4
JournalProteomics - Clinical Applications
Volume3
Issue number10
DOIs
StatePublished - Nov 11 2009

Keywords

  • Albuminome
  • Biomarker
  • Carrier protein
  • Complement
  • MS

ASJC Scopus subject areas

  • Clinical Biochemistry

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