The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid

Stephen B. Mason, Xianyin Lai, Robert Bacallao, Bonnie L. Biazer-Yost, Vincent H. Gattone, Kevin C. Wang, Frank Witzmann

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid-filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow-up experiment, we hypothesized that the protein-bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.

Original languageEnglish
Pages (from-to)1247-1250
Number of pages4
JournalProteomics - Clinical Applications
Volume3
Issue number10
DOIs
StatePublished - 2009

Fingerprint

Cyst Fluid
Autosomal Dominant Polycystic Kidney
Biomarkers
Proteome
Fluids
Kidney
Proteins
Molecules
Experiments

Keywords

  • Albuminome
  • Biomarker
  • Carrier protein
  • Complement
  • MS

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid. / Mason, Stephen B.; Lai, Xianyin; Bacallao, Robert; Biazer-Yost, Bonnie L.; Gattone, Vincent H.; Wang, Kevin C.; Witzmann, Frank.

In: Proteomics - Clinical Applications, Vol. 3, No. 10, 2009, p. 1247-1250.

Research output: Contribution to journalArticle

Mason, Stephen B. ; Lai, Xianyin ; Bacallao, Robert ; Biazer-Yost, Bonnie L. ; Gattone, Vincent H. ; Wang, Kevin C. ; Witzmann, Frank. / The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid. In: Proteomics - Clinical Applications. 2009 ; Vol. 3, No. 10. pp. 1247-1250.
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