The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program

Jose C. Florez, Elizabeth Barrett-Connor, Kathleen A. Jablonski, William C. Knowler, Andrew Taylor, Alan R. Shuldiner, Kieren Mather, Toni I. Pollin, Edward Horton, Neil H. White

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - The C allele at the rs11212617 polymorphism in the ataxia-telangiectasia-mutated (ATM) gene has been associated with greater clinical response to metformin in people with type 2 diabetes. We tested whether this variant modified the effect of metformin in the Diabetes Prevention Program (DPP), in which metformin reduced diabetes incidence by 31% in volunteers with impaired glucose tolerance. RESEARCH DESIGN AND METHODS - We genotyped rs11212617 in 2,994 DPP participants and analyzed its effects on diabetes incidence and related traits. RESULTS - Contrary to expectations, C carriers enjoyed no preventive advantage on metformin; their hazard ratio, comparedwith A carriers,was 1.17 ([95% CI 0.96-1.42], P = 0.13) under metformin. There were no significant differences by genotype in metformin's effects on insulin sensitivity, fasting glucose, glycated hemoglobin, or disposition index. CONCLUSIONS - The reported association of rs11212617 with metformin response was not confirmed for diabetes prevention or for effects on relevant physiologic parameters in the DPP.

Original languageEnglish
Pages (from-to)1864-1867
Number of pages4
JournalDiabetes Care
Volume35
Issue number9
DOIs
StatePublished - Sep 2012

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Ataxia Telangiectasia
Metformin
Alleles
Glucose Intolerance
Incidence
Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Insulin Resistance
Volunteers
Fasting
Research Design
Genotype
Glucose
Genes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Florez, J. C., Barrett-Connor, E., Jablonski, K. A., Knowler, W. C., Taylor, A., Shuldiner, A. R., ... White, N. H. (2012). The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program. Diabetes Care, 35(9), 1864-1867. https://doi.org/10.2337/dc11-2301

The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program. / Florez, Jose C.; Barrett-Connor, Elizabeth; Jablonski, Kathleen A.; Knowler, William C.; Taylor, Andrew; Shuldiner, Alan R.; Mather, Kieren; Pollin, Toni I.; Horton, Edward; White, Neil H.

In: Diabetes Care, Vol. 35, No. 9, 09.2012, p. 1864-1867.

Research output: Contribution to journalArticle

Florez, JC, Barrett-Connor, E, Jablonski, KA, Knowler, WC, Taylor, A, Shuldiner, AR, Mather, K, Pollin, TI, Horton, E & White, NH 2012, 'The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program', Diabetes Care, vol. 35, no. 9, pp. 1864-1867. https://doi.org/10.2337/dc11-2301
Florez JC, Barrett-Connor E, Jablonski KA, Knowler WC, Taylor A, Shuldiner AR et al. The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program. Diabetes Care. 2012 Sep;35(9):1864-1867. https://doi.org/10.2337/dc11-2301
Florez, Jose C. ; Barrett-Connor, Elizabeth ; Jablonski, Kathleen A. ; Knowler, William C. ; Taylor, Andrew ; Shuldiner, Alan R. ; Mather, Kieren ; Pollin, Toni I. ; Horton, Edward ; White, Neil H. / The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program. In: Diabetes Care. 2012 ; Vol. 35, No. 9. pp. 1864-1867.
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