The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration

Bruce Wightman, Scott G. Clark, Anna M. Taskar, Wayne Forrester, Andres V. Maricq, Cornelia I. Bargmann, Gian Garriga

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The assembly of the nervous system in the nematode C. elegans requires the directed migrations of cells and growth cones along the anteroposterior and dorsoventral body axis. We show here that the gene vab-8 is essential for most posteriorly directed migrations of cells and growth cones. Mutations in vab-8 disrupt fourteen of seventeen posteriorly directed migrations, but only two of seventeen anteriorly directed and dorsoventral migrations. For two types of neurons that extend axons both anteriorly and posteriorly, vab-8 mutations disrupt only the growth of the posteriorly directed axon. vab-8 encodes two genetic activities that function in the guidance of different migrations. Our results suggest that most posteriorly directed cell and growth cone migrations are guided by a common mechanism involving the vab-8 gene.

Original languageEnglish (US)
Pages (from-to)671-682
Number of pages12
JournalDevelopment (Cambridge)
Volume122
Issue number2
StatePublished - Feb 1996
Externally publishedYes

Fingerprint

Growth Cones
Cell Movement
Axons
Genes
Mutation
Nervous System
Neurons
Growth
Neuronal Outgrowth

Keywords

  • Anterior-posterior axis
  • Axon guidance
  • C. elegans
  • Cell migration
  • Pathfinding
  • vab-8 gene

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Wightman, B., Clark, S. G., Taskar, A. M., Forrester, W., Maricq, A. V., Bargmann, C. I., & Garriga, G. (1996). The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. Development (Cambridge), 122(2), 671-682.

The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. / Wightman, Bruce; Clark, Scott G.; Taskar, Anna M.; Forrester, Wayne; Maricq, Andres V.; Bargmann, Cornelia I.; Garriga, Gian.

In: Development (Cambridge), Vol. 122, No. 2, 02.1996, p. 671-682.

Research output: Contribution to journalArticle

Wightman, B, Clark, SG, Taskar, AM, Forrester, W, Maricq, AV, Bargmann, CI & Garriga, G 1996, 'The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration', Development (Cambridge), vol. 122, no. 2, pp. 671-682.
Wightman B, Clark SG, Taskar AM, Forrester W, Maricq AV, Bargmann CI et al. The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. Development (Cambridge). 1996 Feb;122(2):671-682.
Wightman, Bruce ; Clark, Scott G. ; Taskar, Anna M. ; Forrester, Wayne ; Maricq, Andres V. ; Bargmann, Cornelia I. ; Garriga, Gian. / The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. In: Development (Cambridge). 1996 ; Vol. 122, No. 2. pp. 671-682.
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