The c-kit signaling pathway is involved in the development of persistent pain

Yan Gang Sun, Neilia G. Gracias, Julie Kosto Drobish, Michael R. Vasko, Robert W. Gereau, Zhou Feng Chen

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Protein kinase signal transduction pathways play critical roles in regulating nociception. Here we show that c-kit, a tyrosine kinase receptor, is expressed in lamina I and II layer of the dorsal horn. Moreover, the superficial c-kit+ fibers originate from the dorsal root ganglion, and c-kit in lamina II inner layer comes from intrinsic expression of the spinal cord. KitW-v mice, which contain a hypomorphic mutation, exhibited normal acute pain in most pain behavior tests. In the formalin test, the first phase was not affected, whereas the second phase pain response of KitW-v mice was significantly reduced relative to wild-type littermates. KitW-v mice also showed abnormal neuropathic pain, notably in the contralateral side of nerve injury. The expression and release of CGRP and substance P were not altered by the c-kit mutation. Together, these results implicate c-kit-mediated signal transduction in the development of persistent pain.

Original languageEnglish (US)
Pages (from-to)178-186
Number of pages9
JournalPain
Volume144
Issue number1-2
DOIs
StatePublished - Jul 1 2009

Keywords

  • c-kit
  • CCI
  • DRG
  • Formalin test
  • Persistent pain
  • Spinal cord
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

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  • Cite this

    Sun, Y. G., Gracias, N. G., Drobish, J. K., Vasko, M. R., Gereau, R. W., & Chen, Z. F. (2009). The c-kit signaling pathway is involved in the development of persistent pain. Pain, 144(1-2), 178-186. https://doi.org/10.1016/j.pain.2009.04.011