The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration

Wayne C. Forrester, Changsung Kim, Gian Garriga

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

During Caenorhabditis elegans development, the HSN neurons and the right Q neuroblast and its descendants undergo long-range anteriorly directed migrations. Both of these migrations require EGL-20, a C. elegans Wnt homolog. Through a canonical Wnt signaling pathway, EGL-20/Wnt transcriptionally activates the Hox gene mab-5 in the left Q neuroblast and its descendants, causing the cells to migrate posteriorly. In this report, we show that CAM-1, a Ror receptor tyrosine kinase (RTK) family member, inhibits EGL-20 signaling. Excess EGL-20, like loss of cam-1, caused the HSNs to migrate too far anteriorly. Excess CAM-1, like loss of egl-20, shifted the final positions of the HSNs posteriorly and caused the left Q neuroblast descendants to migrate anteriorly. The reversal in the migration of the left Q neuroblast and its descendants resulted from a failure to express mab-5, an egl-20 mutant phenotype. Our data suggest that CAM-1 negatively regulates EGL-20.

Original languageEnglish (US)
Pages (from-to)1951-1962
Number of pages12
JournalGenetics
Volume168
Issue number4
DOIs
StatePublished - Dec 1 2004

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Wnt Signaling Pathway
Caenorhabditis elegans
Receptor Protein-Tyrosine Kinases
Cell Movement
Homeobox Genes
Phenotype
Neurons

ASJC Scopus subject areas

  • Genetics

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The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. / Forrester, Wayne C.; Kim, Changsung; Garriga, Gian.

In: Genetics, Vol. 168, No. 4, 01.12.2004, p. 1951-1962.

Research output: Contribution to journalArticle

Forrester, Wayne C. ; Kim, Changsung ; Garriga, Gian. / The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. In: Genetics. 2004 ; Vol. 168, No. 4. pp. 1951-1962.
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