The cancer genomics resource list 2014

Mary M. Zutter, Kenneth J. Bloom, Liang Cheng, Ian S. Hagemann, Jill H. Kaufman, Alyssa M. Krasinskas, Alexander J. Lazar, Debra G.B. Leonard, Neal I. Lindeman, Ann M. Moyer, Marina N. Nikiforova, Jan A. Nowak, John D. Pfeifer, Antonia R. Sepulveda, Joseph E. Willis, Sophia L. Yohe

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Context.-Genomic sequencing for cancer is offered by commercial for-profit laboratories, independent laboratory networks, and laboratories in academic medical centers and integrated health networks. The variability among the tests has created a complex, confusing environment. Objective.-To address the complexity, the Personalized Health Care (PHC) Committee of the College of American Pathologists proposed the development of a cancer genomics resource list (CGRL). The goal of this resource was to assist the laboratory pathology and clinical oncology communities. Design.-The PHC Committee established a working group in 2012 to address this goal. The group consisted of site-specific experts in cancer genetic sequencing. The group identified current next-generation sequencing (NGS)-based cancer tests and compiled them into a usable resource. The genes were annotated by the working group. The annotation process drew on published knowledge, including public databases and the medical literature. Results.-The compiled list includes NGS panels offered by 19 laboratories or vendors, accompanied by annotations. The list has 611 different genes for which NGS-based mutation testing is offered. Surprisingly, of these 611 genes, 0 genes were listed in every panel, 43 genes were listed in 4 panels, and 54 genes were listed in 3 panels. In addition, tests for 393 genes were offered by only 1 or 2 institutions. Table 1 provides an example of gene mutations offered for breast cancer genomic testing with the annotation as it appears in the CGRL 2014. Conclusions.-The final product, referred to as the Cancer Genomics Resource List 2014, is available as supplemental digital content.

Original languageEnglish (US)
Pages (from-to)989-1008
Number of pages20
JournalArchives of Pathology and Laboratory Medicine
Volume139
Issue number8
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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    Zutter, M. M., Bloom, K. J., Cheng, L., Hagemann, I. S., Kaufman, J. H., Krasinskas, A. M., Lazar, A. J., Leonard, D. G. B., Lindeman, N. I., Moyer, A. M., Nikiforova, M. N., Nowak, J. A., Pfeifer, J. D., Sepulveda, A. R., Willis, J. E., & Yohe, S. L. (2015). The cancer genomics resource list 2014. Archives of Pathology and Laboratory Medicine, 139(8), 989-1008. https://doi.org/10.5858/arpa.2014-0330-CP