The Cardiac Neural Crest and Their Role in Development and Disease

Joshua W. Vincentz, Anthony B. Firulli

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Neural crest cells (NCC) are a multipotent progenitor cell population that can generate both ectodermal cell types, such as neurons, and mesodermal cell types, such as muscle. The cardiac NCC (cNCC) play key roles in the formation of the cardiac outflow tract (OFT), by which NCC migrate into the embryonic heart and contribute to formation of the pharyngeal arch arteries that subsequently remodel to establish the connections of the dorsal aorta and pulmonary arteries to the left and right ventricles, respectively. The cNCC also contribute to the aortic and pulmonary valves, thereby connecting the heart to the vascular system. This complex process involves cell delamination, migration, fate specification, and ultimately differentiation into the required tissue types. Behind the scenes of these processes are signaling molecules and transcriptional regulators that orchestrate each of these developmental events. In this chapter, we explore what is known regarding the genesis and development of the cNCC.

Original languageEnglish (US)
Title of host publicationNeural Crest Cells
Subtitle of host publicationEvolution, Development and Disease
PublisherElsevier Inc.
Pages205-229
Number of pages25
ISBN (Print)9780124017306
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cell differentiation
  • Cell specification
  • Congenital heart defects
  • Heart development
  • Transcriptional regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Vincentz, J. W., & Firulli, A. B. (2014). The Cardiac Neural Crest and Their Role in Development and Disease. In Neural Crest Cells: Evolution, Development and Disease (pp. 205-229). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-401730-6.00012-0