The cardiomyocyte cell cycle

Pascal J.E. Lafontant, Loren J. Field

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

Many forms of cardiac disease are characterized by cardiomyocyte death due to necrosis, apoptosis and/or oncosis. Recently, the notion of promoting cardiac regeneration as a means to replace damaged heart tissue has engendered considerable interest. One approach to accomplish heart muscle regeneration entails promoting cardiomyocyte cell cycle activity in the surviving myocardium. Genetically modified mice have provided useful model systems to test the efficacy of specific pathways to promote cardiomyocyte proliferation in normal and diseased hearts. For example, expression of a heart-restricted dominant interfering version of p193 (an E3 ubiquitin ligase also known as Cul7) resulted in an induction of cardiomyocyte cell cycle activity at the infarct border zone and ventricular septum 4 weeks after permanent coronary artery occlusion. A concomitant reduction in hypertrophic cardiomyocyte growth was also observed in this model, suggesting that cell cycle activation partially counteracted the adverse ventricular remodelling that occurs post-infarction. In other studies, targeted expression of cyclin D2 promoted cardiomyocyte cell cycle activity in adult hearts. The level of cardiomyocyte cell cycle activity increased after myocardial infarction, ultimately resulting in a marked increase in cardiomyocyte number and a concomitant regression of infarct size. Collectively, these data suggest that modulation of cardiomyocyte cell cycle activity can be exploited to promote regenerative growth in injured hearts.

Original languageEnglish (US)
Title of host publicationHeart Failure
Subtitle of host publicationMolecules, Mechanisms and Therapeutic Targets
Pages196-207
Number of pages12
StatePublished - 2006

Publication series

NameNovartis Foundation Symposium
Volume274
ISSN (Print)1528-2511

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The cardiomyocyte cell cycle'. Together they form a unique fingerprint.

  • Cite this

    Lafontant, P. J. E., & Field, L. J. (2006). The cardiomyocyte cell cycle. In Heart Failure: Molecules, Mechanisms and Therapeutic Targets (pp. 196-207). (Novartis Foundation Symposium; Vol. 274).