The case against prophylactic cranial irradiation in limited small cell lung cancer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

There have been significant advances in the treatment of small cell lung cancer during the past two decades. Systemic chemotherapy for extensive disease and combined modality therapy for limited small cell lung cancer has improved both quality and quantity of survival. In extensive disease, although the median survival time is improved with chemotherapy, only rarely is a patient cured. However, in limited disease, over 50% of the patients will achieve a complete remission and the 5-year survival is approximately 20%. There has been significant controversy concerning the role of prophylactic cranial irradiation, especially in patients with limited small cell lung cancer who achieve a complete remission. This article addresses the currently available data concerning benefit, toxicity, and results from randomized clinical trials using prophylactic cranial irradiation in patients with small cell lung cancer.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalSeminars in Radiation Oncology
Volume5
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Cranial Irradiation
Small Cell Lung Carcinoma
lungs
cancer
irradiation
chemotherapy
Survival
Drug Therapy
Combined Modality Therapy
toxicity
therapy
Randomized Controlled Trials

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

The case against prophylactic cranial irradiation in limited small cell lung cancer. / Einhorn, Lawrence.

In: Seminars in Radiation Oncology, Vol. 5, No. 1, 1995, p. 57-60.

Research output: Contribution to journalArticle

@article{c827e17b67894e9a9adddb1be5aba6da,
title = "The case against prophylactic cranial irradiation in limited small cell lung cancer",
abstract = "There have been significant advances in the treatment of small cell lung cancer during the past two decades. Systemic chemotherapy for extensive disease and combined modality therapy for limited small cell lung cancer has improved both quality and quantity of survival. In extensive disease, although the median survival time is improved with chemotherapy, only rarely is a patient cured. However, in limited disease, over 50{\%} of the patients will achieve a complete remission and the 5-year survival is approximately 20{\%}. There has been significant controversy concerning the role of prophylactic cranial irradiation, especially in patients with limited small cell lung cancer who achieve a complete remission. This article addresses the currently available data concerning benefit, toxicity, and results from randomized clinical trials using prophylactic cranial irradiation in patients with small cell lung cancer.",
author = "Lawrence Einhorn",
year = "1995",
doi = "10.1016/S1053-4296(05)80011-6",
language = "English",
volume = "5",
pages = "57--60",
journal = "Seminars in Radiation Oncology",
issn = "1053-4296",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - The case against prophylactic cranial irradiation in limited small cell lung cancer

AU - Einhorn, Lawrence

PY - 1995

Y1 - 1995

N2 - There have been significant advances in the treatment of small cell lung cancer during the past two decades. Systemic chemotherapy for extensive disease and combined modality therapy for limited small cell lung cancer has improved both quality and quantity of survival. In extensive disease, although the median survival time is improved with chemotherapy, only rarely is a patient cured. However, in limited disease, over 50% of the patients will achieve a complete remission and the 5-year survival is approximately 20%. There has been significant controversy concerning the role of prophylactic cranial irradiation, especially in patients with limited small cell lung cancer who achieve a complete remission. This article addresses the currently available data concerning benefit, toxicity, and results from randomized clinical trials using prophylactic cranial irradiation in patients with small cell lung cancer.

AB - There have been significant advances in the treatment of small cell lung cancer during the past two decades. Systemic chemotherapy for extensive disease and combined modality therapy for limited small cell lung cancer has improved both quality and quantity of survival. In extensive disease, although the median survival time is improved with chemotherapy, only rarely is a patient cured. However, in limited disease, over 50% of the patients will achieve a complete remission and the 5-year survival is approximately 20%. There has been significant controversy concerning the role of prophylactic cranial irradiation, especially in patients with limited small cell lung cancer who achieve a complete remission. This article addresses the currently available data concerning benefit, toxicity, and results from randomized clinical trials using prophylactic cranial irradiation in patients with small cell lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=0028885346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028885346&partnerID=8YFLogxK

U2 - 10.1016/S1053-4296(05)80011-6

DO - 10.1016/S1053-4296(05)80011-6

M3 - Article

AN - SCOPUS:0028885346

VL - 5

SP - 57

EP - 60

JO - Seminars in Radiation Oncology

JF - Seminars in Radiation Oncology

SN - 1053-4296

IS - 1

ER -