The cause of idiopathic calcium stone disease: Hypercalciuria or hyperoxaluria?

W. G. Robertson, M. Peacock

Research output: Contribution to journalArticle

212 Scopus citations

Abstract

Hypercalciuria is common in patients who form calcium oxalate urinary stones and is considered by many to be the cause of the disorder. The review shows that there is little relationship between either the rate of stone-formation or calcium oxalate crystalluria and the urinary excretion of calcium. There is, however, a strong relationship between these parameters and the urinary excretion of oxalate which is slightly, but significantly, elevated in stone-formers compared with normals. It is concluded that this mild degree of hyperoxaluria may be much more important than hypercalciuria in the genesis of calcium oxalate stones.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalNephron
Volume26
Issue number3
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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