The cell cycle inhibitors p21(WAF1) and p27(KIP1) are associated with survival in patients treated by salvage prostatectomy after radiation therapy

Liang Cheng, Ricardo V. Lloyd, Amy L. Weaver, Thomas M. Pisansky, John C. Cheville, Dharamdas M. Ramnani, Bradley C. Leibovich, Michael L. Blute, Horst Zincke, David G. Bostwich

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Abstract

We evaluated p27(KIP1) and p21(WAF1) expression in 52 patients treated by salvage radical prostatectomy and bilateral pelvic lymphadenectomy for biopsy-proven locally persistent or recurrent prostate cancer after external beam radiation therapy. We defined low and high expression based on the median value observed in our sample. Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p21 (≤5%), compared with 94 and 100%, respectively, for those with high expression of p21 (>5%; P = 0.02 and 0.01, respectively). Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p27 (<50%), compared with 88 and 96%, respectively, for those with high expression of p27 (≥50%; P = 0.06 and 0.01, respectively). These findings indicate that p21 and p27 expression levels are significant predictors of survival for patients selected for salvage prostatectomy for recurrent prostate cancer.

Original languageEnglish
Pages (from-to)1896-1899
Number of pages4
JournalClinical Cancer Research
Volume6
Issue number5
StatePublished - May 2000

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Prostatectomy
Cell Cycle
Radiotherapy
Survival
Prostatic Neoplasms
Neoplasm Metastasis
Lymph Node Excision
Neoplasms
Biopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cheng, L., Lloyd, R. V., Weaver, A. L., Pisansky, T. M., Cheville, J. C., Ramnani, D. M., ... Bostwich, D. G. (2000). The cell cycle inhibitors p21(WAF1) and p27(KIP1) are associated with survival in patients treated by salvage prostatectomy after radiation therapy. Clinical Cancer Research, 6(5), 1896-1899.

The cell cycle inhibitors p21(WAF1) and p27(KIP1) are associated with survival in patients treated by salvage prostatectomy after radiation therapy. / Cheng, Liang; Lloyd, Ricardo V.; Weaver, Amy L.; Pisansky, Thomas M.; Cheville, John C.; Ramnani, Dharamdas M.; Leibovich, Bradley C.; Blute, Michael L.; Zincke, Horst; Bostwich, David G.

In: Clinical Cancer Research, Vol. 6, No. 5, 05.2000, p. 1896-1899.

Research output: Contribution to journalArticle

Cheng, L, Lloyd, RV, Weaver, AL, Pisansky, TM, Cheville, JC, Ramnani, DM, Leibovich, BC, Blute, ML, Zincke, H & Bostwich, DG 2000, 'The cell cycle inhibitors p21(WAF1) and p27(KIP1) are associated with survival in patients treated by salvage prostatectomy after radiation therapy', Clinical Cancer Research, vol. 6, no. 5, pp. 1896-1899.
Cheng, Liang ; Lloyd, Ricardo V. ; Weaver, Amy L. ; Pisansky, Thomas M. ; Cheville, John C. ; Ramnani, Dharamdas M. ; Leibovich, Bradley C. ; Blute, Michael L. ; Zincke, Horst ; Bostwich, David G. / The cell cycle inhibitors p21(WAF1) and p27(KIP1) are associated with survival in patients treated by salvage prostatectomy after radiation therapy. In: Clinical Cancer Research. 2000 ; Vol. 6, No. 5. pp. 1896-1899.
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