The centrosome and mitotic spindle apparatus in cancer and senescence

Stephan Schmidt, Frank Essmann, Ion C. Cirstea, Fabian Kuck, Harish C. Thakur, Madhurendra Singh, Anja Kletke, Reiner U. Jänicke, Constanze Wiek, Helmut Hanenberg, M. Reza Ahmadian, Klaus Schulze-Osthoff, Bernd Nürnberg, Roland P. Piekorz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular senescence. We have compiled recent evidence that inhibition or depletion of various mitotic proteins which take over key roles in centrosome and kinetochore integrity and mitotic checkpoint function is sufficient to activate a p53-p21WAF driven premature senescence phenotype. These findings have direct implications for proliferative tissue homeostasis as well as for cellular and organismal aging.

Original languageEnglish
Pages (from-to)4469-4473
Number of pages5
JournalCell Cycle
Volume9
Issue number22
DOIs
StatePublished - Nov 15 2010

Fingerprint

Centrosome
Spindle Apparatus
Cell Aging
Carcinogenesis
M Phase Cell Cycle Checkpoints
Kinetochores
Cell Division
Neoplasms
Cell Cycle
Proteins
Homeostasis
Phenotype

Keywords

  • Cancer
  • Centrosome
  • Kinetochore
  • Mitotic checkpoint
  • p21
  • p53
  • Senescence

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Schmidt, S., Essmann, F., Cirstea, I. C., Kuck, F., Thakur, H. C., Singh, M., ... Piekorz, R. P. (2010). The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle, 9(22), 4469-4473. https://doi.org/10.4161/cc.9.22.13684

The centrosome and mitotic spindle apparatus in cancer and senescence. / Schmidt, Stephan; Essmann, Frank; Cirstea, Ion C.; Kuck, Fabian; Thakur, Harish C.; Singh, Madhurendra; Kletke, Anja; Jänicke, Reiner U.; Wiek, Constanze; Hanenberg, Helmut; Ahmadian, M. Reza; Schulze-Osthoff, Klaus; Nürnberg, Bernd; Piekorz, Roland P.

In: Cell Cycle, Vol. 9, No. 22, 15.11.2010, p. 4469-4473.

Research output: Contribution to journalArticle

Schmidt, S, Essmann, F, Cirstea, IC, Kuck, F, Thakur, HC, Singh, M, Kletke, A, Jänicke, RU, Wiek, C, Hanenberg, H, Ahmadian, MR, Schulze-Osthoff, K, Nürnberg, B & Piekorz, RP 2010, 'The centrosome and mitotic spindle apparatus in cancer and senescence', Cell Cycle, vol. 9, no. 22, pp. 4469-4473. https://doi.org/10.4161/cc.9.22.13684
Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M et al. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle. 2010 Nov 15;9(22):4469-4473. https://doi.org/10.4161/cc.9.22.13684
Schmidt, Stephan ; Essmann, Frank ; Cirstea, Ion C. ; Kuck, Fabian ; Thakur, Harish C. ; Singh, Madhurendra ; Kletke, Anja ; Jänicke, Reiner U. ; Wiek, Constanze ; Hanenberg, Helmut ; Ahmadian, M. Reza ; Schulze-Osthoff, Klaus ; Nürnberg, Bernd ; Piekorz, Roland P. / The centrosome and mitotic spindle apparatus in cancer and senescence. In: Cell Cycle. 2010 ; Vol. 9, No. 22. pp. 4469-4473.
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