The centrosome and mitotic spindle apparatus in cancer and senescence

Stephan Schmidt, Frank Essmann, Ion C. Cirstea, Fabian Kuck, Harish C. Thakur, Madhurendra Singh, Anja Kletke, Reiner U. Jänicke, Constanze Wiek, Helmut Hanenberg, M. Reza Ahmadian, Klaus Schulze-Osthoff, Bernd Nürnberg, Roland P. Piekorz

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular senescence. We have compiled recent evidence that inhibition or depletion of various mitotic proteins which take over key roles in centrosome and kinetochore integrity and mitotic checkpoint function is sufficient to activate a p53-p21WAF driven premature senescence phenotype. These findings have direct implications for proliferative tissue homeostasis as well as for cellular and organismal aging.

Original languageEnglish (US)
Pages (from-to)4469-4473
Number of pages5
JournalCell Cycle
Volume9
Issue number22
DOIs
StatePublished - Nov 15 2010

Keywords

  • Cancer
  • Centrosome
  • Kinetochore
  • Mitotic checkpoint
  • p21
  • p53
  • Senescence

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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  • Cite this

    Schmidt, S., Essmann, F., Cirstea, I. C., Kuck, F., Thakur, H. C., Singh, M., Kletke, A., Jänicke, R. U., Wiek, C., Hanenberg, H., Ahmadian, M. R., Schulze-Osthoff, K., Nürnberg, B., & Piekorz, R. P. (2010). The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle, 9(22), 4469-4473. https://doi.org/10.4161/cc.9.22.13684