The changing face of diabetes in youth: Lessons learned from studies of type 2 diabetes

Tamara S. Hannon, Silva A. Arslanian

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The incidence of youth type 2 diabetes (T2D), linked with obesity and declining physical activity in high-risk populations, is increasing. Recent multicenter studies have led to a number of advances in our understanding of the epidemiology, pathophysiology, diagnosis, treatment, and complications of this disease. As in adult T2D, youth T2D is associated with insulin resistance, together with progressive deterioration in β cell function and relative insulin deficiency in the absence of diabetes-related immune markers. In contrast to adult T2D, the decline in β cell function in youth T2D is three- to fourfold faster, and therapeutic failure rates are significantly higher in youth than in adults. Whether the more aggressive nature of youth T2D is driven by genetic heterogeneity or physiology/metabolic maladaptation is yet unknown. Besides metformin, the lack of approved pharmacotherapeutic agents for youth T2D that target the pathophysiological mechanisms is a major barrier to optimal diabetes management. There is a significant need for effective therapeutic options, in addition to increased prevention, to halt the projected fourfold increase in youth T2D by 2050 and the consequences of heightened diabetes-related morbidity and mortality at younger ages.

Original languageEnglish (US)
Pages (from-to)113-137
Number of pages25
JournalAnnals of the New York Academy of Sciences
Volume1353
Issue number1
DOIs
StatePublished - Sep 2015

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Keywords

  • Adolescent
  • Insulin secretion
  • Insulin sensitivity
  • Obesity
  • Pathophysiology
  • Treatment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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