The changing face of hypophosphatemic disorders in the FGF-23 era.

Janet Y. Lee, Erik A. Imel

Research output: Contribution to journalReview article

21 Scopus citations


In the past decade, research in genetic disorders of hypophosphatemia has significantly expanded our understanding of phosphate metabolism. X-linked hypophosphatemia (XLH) is the most common inherited form of rickets due to renal phosphate wasting. Recent understanding of the mechanisms of disease and role of fibroblast growth factor 23 (FGF-23) in XLH and other hypophosphatemic disorders have opened new potential therapeutic avenues. We will discuss the current standard of treatment for XLH as well as promising future directions under study.

Original languageEnglish (US)
Pages (from-to)367-379
Number of pages13
JournalUnknown Journal
Volume10 Suppl 2
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

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