The chemiluminescent response of human phagocytic cells to mineral dusts

I. P. Gormley, M. J. Kowolik, R. T. Cullen

Research output: Contribution to journalArticle

29 Scopus citations


Luminol-dependent chemiluminescence (CL) was used to assess the in vitro production of reactive oxygen species by human neutrophils and monocytes on exposure to six standard respirable mineral dusts. Every dust caused CL production in both phagocytic cell types, although, for each dust, the two cells showed a different pattern of response. Light output was markedly affected by the presence of serum in the system. While the results illustrated the complexity of the interaction between mineral dusts and monocytes and neutrophils, they did not support the hypothesis that pathogenic dusts would induce the production of more reactive oxygen species than non-pathogenic dusts.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalBritish Journal of Experimental Pathology
Issue number4
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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