The chronic proliferative dermatitis mouse mutation (cpdm)

Mapping of the mutant gene locus

John P. Sundberg, Dawnalyn Boggess, Leonard D. Shultz, Remond J A Fijneman, Peter Demant, Harm HogenEsch, Gregory A. Cox

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The chronic proliferative dermatitis (cpdm) mouse mutation was mapped to mouse Chromosome 15 using an intraspecific cross between C57BL/KaLawRij cpdm/cpdm and BALB/cJ mice. A second autosomal recessive mutation that resulted in a phenotype similar to that of cpdm arose spontaneously in a colony of OcB-3/Dem recombinant congenic mice. This new mutation was found to be allelic with cpdm. Therefore, the gene symbol for the allelic mutation is cpdm(Dem). The phenotype of these mutant mice consists of eosinophil-driven severe and progressive inflammatory changes in multiple organs including the skin and lungs.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalJournal of Experimental Animal Science
Volume41
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Chromosome Mapping
Dermatitis
dermatitis
mutation
mutants
Mutation
loci
mice
genes
Congenic Mice
Phenotype
Chromosomes, Human, Pair 15
phenotype
Eosinophils
eosinophils
skin (animal)
lungs
Lung
Skin
chromosomes

Keywords

  • Asthma
  • Atopy
  • Eosinophil
  • Human chromosome 22
  • Human chromosome 8
  • Mouse Chromosome 15
  • Psoriasiform dermatitis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Sundberg, J. P., Boggess, D., Shultz, L. D., Fijneman, R. J. A., Demant, P., HogenEsch, H., & Cox, G. A. (2000). The chronic proliferative dermatitis mouse mutation (cpdm): Mapping of the mutant gene locus. Journal of Experimental Animal Science, 41(3), 101-108.

The chronic proliferative dermatitis mouse mutation (cpdm) : Mapping of the mutant gene locus. / Sundberg, John P.; Boggess, Dawnalyn; Shultz, Leonard D.; Fijneman, Remond J A; Demant, Peter; HogenEsch, Harm; Cox, Gregory A.

In: Journal of Experimental Animal Science, Vol. 41, No. 3, 2000, p. 101-108.

Research output: Contribution to journalArticle

Sundberg, JP, Boggess, D, Shultz, LD, Fijneman, RJA, Demant, P, HogenEsch, H & Cox, GA 2000, 'The chronic proliferative dermatitis mouse mutation (cpdm): Mapping of the mutant gene locus', Journal of Experimental Animal Science, vol. 41, no. 3, pp. 101-108.
Sundberg, John P. ; Boggess, Dawnalyn ; Shultz, Leonard D. ; Fijneman, Remond J A ; Demant, Peter ; HogenEsch, Harm ; Cox, Gregory A. / The chronic proliferative dermatitis mouse mutation (cpdm) : Mapping of the mutant gene locus. In: Journal of Experimental Animal Science. 2000 ; Vol. 41, No. 3. pp. 101-108.
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