The chronic proliferative dermatitis mouse mutation (cpdm): Mapping of the mutant gene locus

John P. Sundberg, Dawnalyn Boggess, Leonard D. Shultz, Remond J.A. Fijneman, Peter Demant, Harm Hogenesch, Gregory A. Cox

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The chronic proliferative dermatitis (cpdm) mouse mutation was mapped to mouse Chromosome 15 using an intraspecific cross between C57BL/KaLawRij cpdm/cpdm and BALB/cJ mice. A second autosomal recessive mutation that resulted in a phenotype similar to that of cpdm arose spontaneously in a colony of OcB-3/Dem recombinant congenic mice. This new mutation was found to be allelic with cpdm. Therefore, the gene symbol for the allelic mutation is cpdm(Dem). The phenotype of these mutant mice consists of eosinophil-driven severe and progressive inflammatory changes in multiple organs including the skin and lungs.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalJournal of Experimental Animal Science
Volume41
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Asthma
  • Atopy
  • Eosinophil
  • Human chromosome 22
  • Human chromosome 8
  • Mouse Chromosome 15
  • Psoriasiform dermatitis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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