The clinical and therapeutic implications of cancer stem cell biology

Liang Cheng, Riley Alexander, Shaobo Zhang, Chong Xian Pan, Gregory T. MacLennan, Antonio Lopez-Beltran, Rodolfo Montironi

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Cancer stem cells (CSCs) have provided new insights into the tumorigenesis and metastatic potential of cancer. The discovery of CSCs has provided many new insights into the complexities of cancer therapy: tumor initiation, treatment resistance, metastasis, recurrence, assessment of prognosis and prediction of clinical course. Recent rapid advances in molecular analysis have contributed to the better understanding of the molecular attributes and pathways that give CSCs their unique attributes. Use of these molecular techniques has facilitated elucidation of specific surface markers and pathways that favor propagation of CSCs - allowing for targeted therapy. Furthermore, it has been discovered that a specific microenvironment, or niche, is essential for the genesis of tumors from CSCs. Therapeutic strategies that alter these microenvironments compromise CSC proliferation and constitute another method of targeted cancer therapy. We review the clinical and therapeutic implications of CSCs, with a focus on treatment resistance and metastasis, and the emerging approaches to target CSCs and their microenvironments in order to attain improved outcomes in cancer. It is noteworthy that CSCs are the only cells capable of sustaining tumorigenesis; however, the cell of origin of cancer, in which tumorigenesis is initiated, may be distinct from CSCs that propagate the tumor.

Original languageEnglish (US)
Pages (from-to)1133-1145
Number of pages13
JournalExpert Review of Anticancer Therapy
Volume11
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • cancer stem cell
  • mesenchymal stem cell
  • metastasis
  • pathway targeting
  • personalized medicine
  • targeted therapy
  • tumorigenesis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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  • Cite this

    Cheng, L., Alexander, R., Zhang, S., Pan, C. X., MacLennan, G. T., Lopez-Beltran, A., & Montironi, R. (2011). The clinical and therapeutic implications of cancer stem cell biology. Expert Review of Anticancer Therapy, 11(7), 1133-1145. https://doi.org/10.1586/era.11.82