The clinical behavior of mixed ductal/lobular carcinoma of the breast

A clinicopathologic analysis

Aparna Suryadevara, Lakshmi P. Paruchuri, Nassim Banisaeed, Gary Dunnington, Krishna A. Rao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.Methods: In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.Results: Clinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.Conclusions: Our data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.

Original languageEnglish (US)
Article number51
JournalWorld Journal of Surgical Oncology
Volume8
DOIs
StatePublished - Jun 21 2010
Externally publishedYes

Fingerprint

Lobular Carcinoma
Ductal Carcinoma
Breast
Second Primary Neoplasms
Cadherins
Practice Guidelines
Neoplasms
Coloring Agents
Breast Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

The clinical behavior of mixed ductal/lobular carcinoma of the breast : A clinicopathologic analysis. / Suryadevara, Aparna; Paruchuri, Lakshmi P.; Banisaeed, Nassim; Dunnington, Gary; Rao, Krishna A.

In: World Journal of Surgical Oncology, Vol. 8, 51, 21.06.2010.

Research output: Contribution to journalArticle

Suryadevara, Aparna ; Paruchuri, Lakshmi P. ; Banisaeed, Nassim ; Dunnington, Gary ; Rao, Krishna A. / The clinical behavior of mixed ductal/lobular carcinoma of the breast : A clinicopathologic analysis. In: World Journal of Surgical Oncology. 2010 ; Vol. 8.
@article{3a4ad717cfeb42ab885ae686d2b86b05,
title = "The clinical behavior of mixed ductal/lobular carcinoma of the breast: A clinicopathologic analysis",
abstract = "Background: To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.Methods: In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.Results: Clinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.Conclusions: Our data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.",
author = "Aparna Suryadevara and Paruchuri, {Lakshmi P.} and Nassim Banisaeed and Gary Dunnington and Rao, {Krishna A.}",
year = "2010",
month = "6",
day = "21",
doi = "10.1186/1477-7819-8-51",
language = "English (US)",
volume = "8",
journal = "World Journal of Surgical Oncology",
issn = "1477-7819",
publisher = "BioMed Central",

}

TY - JOUR

T1 - The clinical behavior of mixed ductal/lobular carcinoma of the breast

T2 - A clinicopathologic analysis

AU - Suryadevara, Aparna

AU - Paruchuri, Lakshmi P.

AU - Banisaeed, Nassim

AU - Dunnington, Gary

AU - Rao, Krishna A.

PY - 2010/6/21

Y1 - 2010/6/21

N2 - Background: To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.Methods: In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.Results: Clinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.Conclusions: Our data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.

AB - Background: To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.Methods: In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.Results: Clinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.Conclusions: Our data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.

UR - http://www.scopus.com/inward/record.url?scp=77954867940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954867940&partnerID=8YFLogxK

U2 - 10.1186/1477-7819-8-51

DO - 10.1186/1477-7819-8-51

M3 - Article

VL - 8

JO - World Journal of Surgical Oncology

JF - World Journal of Surgical Oncology

SN - 1477-7819

M1 - 51

ER -