The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding

A six-month study

M. A. Perlich, L. A. Bacca, B. W. Bollmer, A. C. Lanzalaco, S. F. McClanahan, L. K. Sewak, B. B. Beiswanger, W. A. Eichold, J. R. Hull, Richard Jackson, M. S. Mau

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The effects of a stabilized 0.454% stannous fluoride dentifrice, currently marketed as Crest® Gum Care, on supragingival plaque, gingivitis, gingival bleeding and oral soft tissue condition were studied in 328 adult male and female subjects who completed a six-month, double blind clinical study. Following initial examinations, subjects presenting with a minimum of five gingival bleeding sites received a thorough dental prophylaxis and were instructed to brush at least twice a day for three months with a commercially available fluoride dentifrice, packaged in such a way as to blind its identity to the study subjects. This constituted the three-month pre-test period. At the end of this period, subjects were again examined, given a second oral prophylaxis, and randomly assigned to brush with one of the following dentifrices: 1) stabilized 0.454% stannous fluoride, 2) 0.243% sodium fluoride control, or 3) one of three experimental dentifrices. Subjects were instructed to brush their teeth as they normally would, at least twice a day for one minute per brushing. Follow-up examinations after three and six months of dentifrice use evaluated supragingival plaque, gingivitis, gingival bleeding, extrinsic tooth stain and oral soft tissue status. After six months, the stabilized stannous fluoride dentifrice significantly reduced gingivitis and gingival bleeding by 20.5% and 33.4% compared to the sodium fluoride control group. However, the stabilized stannous fluoride dentifrice group was not significantly different from the control dentifrice group with respect to supragingival plaque scores. As expected, accumulation of extrinsic tooth stain was greater in the stabilized stannous fluoride group than the control group. No unexpected nor clinically significant oral soft tissue health effects were associated with the use of the test dentifrices. The results from this clinical study demonstrate that over a six-month period, twice-daily use of a dentifrice containing 0.454% stabilized stannous fluoride significantly reduced gingivitis and gingival bleeding, relative to a 0.243% sodium fluoride control dentifrice.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalJournal of Clinical Dentistry
Volume6
Issue numberSPEC. ISS. II
StatePublished - May 16 1995
Externally publishedYes

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Tin Fluorides
Dentifrices
Gingivitis
Hemorrhage
Sodium Fluoride
Tooth
Control Groups
Coloring Agents
Dental Prophylaxis
Fluorides
Double-Blind Method

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Perlich, M. A., Bacca, L. A., Bollmer, B. W., Lanzalaco, A. C., McClanahan, S. F., Sewak, L. K., ... Mau, M. S. (1995). The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding: A six-month study. Journal of Clinical Dentistry, 6(SPEC. ISS. II), 54-58.

The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding : A six-month study. / Perlich, M. A.; Bacca, L. A.; Bollmer, B. W.; Lanzalaco, A. C.; McClanahan, S. F.; Sewak, L. K.; Beiswanger, B. B.; Eichold, W. A.; Hull, J. R.; Jackson, Richard; Mau, M. S.

In: Journal of Clinical Dentistry, Vol. 6, No. SPEC. ISS. II, 16.05.1995, p. 54-58.

Research output: Contribution to journalArticle

Perlich, MA, Bacca, LA, Bollmer, BW, Lanzalaco, AC, McClanahan, SF, Sewak, LK, Beiswanger, BB, Eichold, WA, Hull, JR, Jackson, R & Mau, MS 1995, 'The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding: A six-month study', Journal of Clinical Dentistry, vol. 6, no. SPEC. ISS. II, pp. 54-58.
Perlich MA, Bacca LA, Bollmer BW, Lanzalaco AC, McClanahan SF, Sewak LK et al. The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding: A six-month study. Journal of Clinical Dentistry. 1995 May 16;6(SPEC. ISS. II):54-58.
Perlich, M. A. ; Bacca, L. A. ; Bollmer, B. W. ; Lanzalaco, A. C. ; McClanahan, S. F. ; Sewak, L. K. ; Beiswanger, B. B. ; Eichold, W. A. ; Hull, J. R. ; Jackson, Richard ; Mau, M. S. / The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding : A six-month study. In: Journal of Clinical Dentistry. 1995 ; Vol. 6, No. SPEC. ISS. II. pp. 54-58.
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