Three triclosan-containing "multi-benefit" dentifrices were compared for clinical eflicacy in reducing supragingival calculus Ibrmation following a dental prophylaxis. A total of 544 subjects completed a double-blind parallel-group clinical study using the Volpe-Manhold Index (VMI) to record severity and occurrence of supragingival calculus. The study design included a pre-test period where the calculus formation rate was measured in subjects brushing with a placebo denti frice. Following a prophylaxis, subjects were stratified forage, gender and VMI scores and assigned to one of four treatments: 1) a dentifrice containing 5.0% soluble pyrophosphate/0.145%, fluoride as NaF/silica abrasive/0.28% triclosan (here-after PPi/TCS - comparable to Crest® Complete dentifrice. Procter & Gamble. UK): 2) a commercial dentifrice containing 2.0% Gantrez™ acid copolymer/0.1457% fluoride as NaF/silica abrasive/0.30% triclosan (hereafter Gan/TCS Colgate® Total dentifrice, Colgate-Palmolive Company, UK): 3) a commercial dentifrice containing 0.5% zinc citrate trihydrate/0.15% fluoride as sodium monofluorophosphate/silica abrasive/0.20% triclosan (hereafter Zn/TCS-Mentadent® Pdentifrice, Unilever, UK); and 4) a control dentifrice comprised of 0.14.5% fluoride as NaF/silica abrasive (hereafter Control). Subjects were instructed to use their assigned dentifrice at least twice per day and to brush as they do normally. Supragingival calculus formation was assessed at two and four months using sitespecific and whole-mouth VMI indices for both calculus severity and occurrence. Following four months of use, the PPi/TCS dentifrice provided statistically significant reductions in calculus severity (22-23%) and occurrence (15%) as compared with the Control dentifrice. The Zn/TCS dentifrice also provided significant reductions in calculus severity (17-19%) and occurrence (12-13%) as compared with the Control. The Gan/TCS produced no statistically signilicant reductions in calculus formation (occurrence or severity) compared with the Control. The PPi/TCS dentifrice provided statistically significant reductions in calculus severity (15-21%) and occurrence (12-16%) as compared with the Gan/TCS dentifrice. These results support the clinical effectiveness of PPi/TCS and Zn/TCS dentifrices for the reduction of supragingival dental calculus formation following a dental pro- phylaxis.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Clinical Dentistry|
|State||Published - Dec 1 1997|
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