The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance

Robert W. Buchanan, Constanze Holstein, Alan Breier

Research output: Contribution to journalArticle

253 Scopus citations


Previous studies have suggested that clozapine may improve neuropsychological test performance. The current study was designed to examine the comparative efficay and the long-term effect of clozapine (versus haloperidol), on neuropsychological test performance. Neuropsychological measures of executive/attention, visuospatial, and memory function were administered to schizophrenic patients at baseline, at the end of a 10-week double-blind study, and after 1 year of open clozapine treatment. Symptoms and funtcion ratings were obtained at the same time points. The 10-week double-blind study revealed significant group-by-time interactions for two measures: Categorical Fluency and WAIS-R Block Design. At the end of 1 year of open treatment there were significant improvements in Verbal Fluency, Mooney Faces Closure, and WAIS-R Block Design performance, and trend improvements in Stroop Color-Word Interference, Category Fluency, and WMS-R Logical Memory performance. Improvements in neuropsychological performance were unrelated to symptom changes. Change in selected neuropsychological measures were signigicantly correlated with improvement in quality of life. The results suggest that long-term clozapine treatment may have beneficial effects on a broad range of cognitive functions.

Original languageEnglish (US)
Pages (from-to)717-725
Number of pages9
JournalBiological psychiatry
Issue number11
StatePublished - Dec 1 1994
Externally publishedYes


  • Schizophrenia
  • clozapine
  • negative symptoms
  • neuropsychological testing
  • positive symptoms
  • quality of life

ASJC Scopus subject areas

  • Biological Psychiatry

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