The comparison of 2-18F-2-deoxyglucose and 15-(ortho-123I-phenyl)-pentadecanoic acid uptake in persisting defects on thallium-201 tomography in myocardial infarction

M. M. Henrich, E. Vester, Elisabeth von der Lohe, H. Herzog, H. Simon, J. T. Kuikka, L. E. Feinendegen

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Abstract

The myocardial uptake of glucose and fatty acids into 201Tl redistribution defects were studied in 32 patients with myocardial infarction by tomography using 2-18F-2-deoxyglucose (FDG) and 15-(ortho-123I-phenyl)-pentadecanoic acid (oPPA). A total of 1153 segments were analyzed, 408 (35%) of which showed a persistent thallium-defect in stress-redistribution images. Of the segments with a decreased 201Tl uptake in these redistribution tomograms, 50.5% had a decreased uptake of both FDG and oPPA; in 21.8% FDG as well as oPPA uptake was within normal range. Normal FDG uptake but decreased oPPA uptake was detected in 17.4%, whereas 10.3% of the segments had normal oPPA uptake but decreased FDG uptake (chi-square test, p <0.001). A significant correlation of FDG and oPPA uptake (r = 0.51) was found in the segments with persistent 201Tl defect. Thus, a substantial fraction of persistent thallium-defects after healed myocardial infarction exhibit FDG as well as oPPA uptake, probably due to residual fatty acid metabolism in partially ischemic regions.

Original languageEnglish (US)
Pages (from-to)1353-1357
Number of pages5
JournalJournal of Nuclear Medicine
Volume32
Issue number7
StatePublished - 1991
Externally publishedYes

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Thallium
Deoxyglucose
Myocardial Infarction
Tomography
Fatty Acids
Chi-Square Distribution
pentadecanoic acid
Reference Values
Glucose

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

The comparison of 2-18F-2-deoxyglucose and 15-(ortho-123I-phenyl)-pentadecanoic acid uptake in persisting defects on thallium-201 tomography in myocardial infarction. / Henrich, M. M.; Vester, E.; von der Lohe, Elisabeth; Herzog, H.; Simon, H.; Kuikka, J. T.; Feinendegen, L. E.

In: Journal of Nuclear Medicine, Vol. 32, No. 7, 1991, p. 1353-1357.

Research output: Contribution to journalArticle

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abstract = "The myocardial uptake of glucose and fatty acids into 201Tl redistribution defects were studied in 32 patients with myocardial infarction by tomography using 2-18F-2-deoxyglucose (FDG) and 15-(ortho-123I-phenyl)-pentadecanoic acid (oPPA). A total of 1153 segments were analyzed, 408 (35{\%}) of which showed a persistent thallium-defect in stress-redistribution images. Of the segments with a decreased 201Tl uptake in these redistribution tomograms, 50.5{\%} had a decreased uptake of both FDG and oPPA; in 21.8{\%} FDG as well as oPPA uptake was within normal range. Normal FDG uptake but decreased oPPA uptake was detected in 17.4{\%}, whereas 10.3{\%} of the segments had normal oPPA uptake but decreased FDG uptake (chi-square test, p <0.001). A significant correlation of FDG and oPPA uptake (r = 0.51) was found in the segments with persistent 201Tl defect. Thus, a substantial fraction of persistent thallium-defects after healed myocardial infarction exhibit FDG as well as oPPA uptake, probably due to residual fatty acid metabolism in partially ischemic regions.",
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AU - Kuikka, J. T.

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