The comparison of 2-18F-2-deoxyglucose and 15-(ortho-123I-phenyl)-pentadecanoic acid uptake in persisting defects on thallium-201 tomography in myocardial infarction

M. M. Henrich, E. Vester, E. Von der Lohe, H. Herzog, H. Simon, J. T. Kuikka, L. E. Feinendegen

Research output: Contribution to journalArticle

25 Scopus citations


The myocardial uptake of glucose and fatty acids into 201Tl redistribution defects were studied in 32 patients with myocardial infarction by tomography using 2-18F-2-deoxyglucose (FDG) and 15-(ortho-123I-phenyl)-pentadecanoic acid (oPPA). A total of 1153 segments were analyzed, 408 (35%) of which showed a persistent thallium-defect in stress-redistribution images. Of the segments with a decreased 201Tl uptake in these redistribution tomograms, 50.5% had a decreased uptake of both FDG and oPPA; in 21.8% FDG as well as oPPA uptake was within normal range. Normal FDG uptake but decreased oPPA uptake was detected in 17.4%, whereas 10.3% of the segments had normal oPPA uptake but decreased FDG uptake (chi-square test, p < 0.001). A significant correlation of FDG and oPPA uptake (r = 0.51) was found in the segments with persistent 201Tl defect. Thus, a substantial fraction of persistent thallium-defects after healed myocardial infarction exhibit FDG as well as oPPA uptake, probably due to residual fatty acid metabolism in partially ischemic regions.

Original languageEnglish (US)
Pages (from-to)1353-1357
Number of pages5
JournalJournal of Nuclear Medicine
Issue number7
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'The comparison of 2-<sup>18</sup>F-2-deoxyglucose and 15-(ortho-<sup>123</sup>I-phenyl)-pentadecanoic acid uptake in persisting defects on thallium-201 tomography in myocardial infarction'. Together they form a unique fingerprint.

  • Cite this