The contribution of bone loss to postmenopausal osteoporosis

Siu Hui, C. W. Slemenda, C. C. Johnston

Research output: Contribution to journalArticle

342 Citations (Scopus)

Abstract

We have addressed the relative importance of peak bone mass and subsequent rate of loss in determining postmenopausal women's bone mass in old age, by examining longitudinal measurements of radial mid-shaft bone mass on various samples of healthy white postmenopausal women. Using both the variance estimate of age-specific rates of bone loss and the population variance in bone mass, we determined that rates of loss could contribute importantly to future bone mass. However, since we found a small negative correlation between initial bone mass and rate of loss, it was necessary to estimate the effect of bone loss as the complement of the contribution of initial bone mass. We found that the influence of bone loss (relative to initial bone mass) increases as the women age, such that by about age 70, the contribution of initial bone mass and rate of loss approached equality. However, estimated rates of bone loss were not very stable over time, so it was difficult to identify long-term 'fast-losers'. We conclude that the rate of postmenopausal bone loss is an important contributor to osteoporosis at old age, but it is difficult to identify long-term fast-losers, thereby reducing the clinical value of assessments of rates of change in bone mass early in the postmenopause.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalOsteoporosis International
Volume1
Issue number1
DOIs
StatePublished - Oct 1990

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Postmenopausal Osteoporosis
Bone and Bones
Postmenopause
Osteoporosis

Keywords

  • Bone loss
  • Bone mass measurements
  • Osteoporosis
  • Peak bone mass
  • Postmenopause
  • Rate of bone loss

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The contribution of bone loss to postmenopausal osteoporosis. / Hui, Siu; Slemenda, C. W.; Johnston, C. C.

In: Osteoporosis International, Vol. 1, No. 1, 10.1990, p. 30-34.

Research output: Contribution to journalArticle

Hui, Siu ; Slemenda, C. W. ; Johnston, C. C. / The contribution of bone loss to postmenopausal osteoporosis. In: Osteoporosis International. 1990 ; Vol. 1, No. 1. pp. 30-34.
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