The contribution of the organic matrix to bone's material properties

David Burr

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Bone is a two-phase porous composite material comprised primarily of collagen and mineral, which together provide its mechanical properties. The contribution of the mineral phase to bone's mechanical properties has dominated scientific thinking. Collagen's role has been underappreciated and not very well studied. However, there is evidence that changes in collagen content, or changes to inter- and intrafibrillar collagen cross-linking, can reduce the energy required to cause bone failure (toughness), and increase fracture risk. Although collagen may have less effect on bone's strength and stiffness than does mineral, it may have a profound effect on bone fragility. Collagen changes that occur with age and reduce bone's toughness may be an important factor in the risk of fracture in older women with low bone mass.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalBone
Volume31
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Bone Matrix
Collagen
Bone and Bones
Minerals

Keywords

  • Biomechanics
  • Collagen
  • Fracture
  • Fragility
  • Osteoporosis

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

The contribution of the organic matrix to bone's material properties. / Burr, David.

In: Bone, Vol. 31, No. 1, 2002, p. 8-11.

Research output: Contribution to journalArticle

Burr, David. / The contribution of the organic matrix to bone's material properties. In: Bone. 2002 ; Vol. 31, No. 1. pp. 8-11.
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