The critical role of clinical pharmacology in geriatric psychopharmacology

B. G. Pollock, C. E. Forsyth, R. R. Bies

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

There is limited geriatrics-oriented clinical pharmacological information available to guide pharmacotherapy in latelife psychiatric disorders. In this paper, we review available data on interindividual differences in drug exposure and central nervous system functioning, amplified by drug-drug interactions in the elderly, that may contribute to variable responses to treatment and significant adverse drug effects. The inclusion of greater numbers of elderly persons in clinical trials and the vigorous application of clinical pharmacologic methodology (i.e., pharmacoepidemiology, population pharmacokinetic modeling, and pharmacogenetics) will be critical for improving safety and personalization of drug and dose selection for elderly patients.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'The critical role of clinical pharmacology in geriatric psychopharmacology'. Together they form a unique fingerprint.

  • Cite this